Squalene 2,3-epoxide cyclizes, forming lanosterol

Stable Identifier
R-HSA-191366
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Lanosterol synthase (LS) catalyzes the cyclization of squalene 2,3-epoxide to lanosterol, a reaction that forms the sterol nucleus.LS is located on the ER membrane and is active as the monomer (Ruf et al, 2004).

Literature References
PubMed ID Title Journal Year
5918048 Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol

Van Tamelen, EE, Willett, JD, Clayton, RB, Lord, KE

J Am Chem Soc 1966
8593458 Molecular cloning of cDNA encoding human lanosterol synthase

Sung, CK, Shibuya, M, Sankawa, U, Ebizuka, Y

Biol Pharm Bull 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lanosterol synthase activity of LSS [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created