Squalene 2,3-epoxide cyclizes, forming lanosterol

Stable Identifier
R-HSA-191366
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Lanosterol synthase (LSS) catalyzes the cyclization of squalene 2,3-epoxide to lanosterol, a reaction that forms the sterol nucleus. LSS is located on the ER membrane and is active in monomeric form (Ruf et al. 2004).
Literature References
PubMed ID Title Journal Year
8593458 Molecular cloning of cDNA encoding human lanosterol synthase

Sankawa, U, Shibuya, M, Ebizuka, Y, Sung, CK

Biol Pharm Bull 1995
5918048 Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol

Van Tamelen, EE, Willett, JD, Clayton, RB, Lord, KE

J Am Chem Soc 1966
Participants
Participates
Catalyst Activity

lanosterol synthase activity of LSS [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!