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FDFT1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-191369
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Farnesyl-diphosphate farnesyltransferase, farnesyltransferase, presqualene-di-diphosphate synthase, squalene synthase
Locations in the PathwayBrowser for interactor UniProt:Q9GZR5
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
FDFT1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
FDFT1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P37268 FDFT1
Gene Names
FDFT1
Chain
chain:1-417
Reference Genes
BioGPS Gene:2222 FDFT1
COSMIC (genes):FDFT1 FDFT1
CTD Gene:2222 FDFT1
dbSNP Gene:2222 FDFT1
ENSEMBL:ENSG00000079459 FDFT1
ENSEMBL_homo_sapiens_GENE:ENSG00000079459.14 FDFT1
ENSEMBL_homo_sapiens_GENE:ENSG00000284967.3 FDFT1
HGNC:3629 FDFT1
KEGG Gene (Homo sapiens):2222 FDFT1
Monarch:2222 FDFT1
NCBI Gene:2222 FDFT1
OMIM:184420 FDFT1
UCSC:P37268 FDFT1
Reference Transcript
RefSeq:NM_001287743.1 FDFT1
RefSeq:XM_017013217.1 FDFT1
RefSeq:NM_001287749.1 FDFT1
RefSeq:NM_001287745.1 FDFT1
RefSeq:NM_001287751.1 FDFT1
RefSeq:NM_001287742.1 FDFT1
RefSeq:NM_004462.4 FDFT1
RefSeq:NM_001287748.1 FDFT1
RefSeq:NM_001287744.1 FDFT1
RefSeq:NM_001287750.1 FDFT1
RefSeq:NM_001287756.1 FDFT1
RefSeq:NM_001287747.1 FDFT1
Other Identifiers
11721242_s_at
11745322_x_at
11748274_s_at
11748275_x_at
11748801_s_at
11754259_x_at
17065811
208647_PM_at
208647_at
210950_PM_s_at
210950_s_at
2222
3086207
3086209
3086210
3086211
3086212
3086213
3086214
3086215
3086216
3086220
3086221
3086222
3086223
3086224
3086225
3086228
3086230
3086231
3086232
3086234
3086237
3086244
3086245
3086246
3086247
3086248
3086249
3086250
3086251
3086252
3086253
34848_at
8144669
A_14_P129904
A_23_P71319
GE59957
GE78948
GO:0003824
GO:0004310
GO:0004311
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0006694
GO:0006695
GO:0008152
GO:0008202
GO:0008203
GO:0008610
GO:0009058
GO:0016020
GO:0016126
GO:0016740
GO:0016765
GO:0043226
GO:0045338
GO:0046872
GO:0051996
HMNXSV003051665
Hs.48876.1.S2_3p_at
ILMN_1741096
ILMN_2144088
PH_hs_0032086
TC08000093.hg
X69141_at
g13097746_3p_a_at
Participates
as an output of
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
as a component of
FDFT:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
fdft1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
erg9 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
FDFT1 [endoplasmic reticulum membrane]
(Bos taurus)
FDFT1 [endoplasmic reticulum membrane]
(Canis familiaris)
FDFT1 [endoplasmic reticulum membrane]
(Gallus gallus)
FDFT1 [endoplasmic reticulum membrane]
(Mus musculus)
FDFT1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
FDFT1 [endoplasmic reticulum membrane]
(Sus scrofa)
ERG9 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
fdfT [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001274680.1
,
NP_004453.3
,
NP_001274685.1
,
XP_016868706.1
,
NP_001274676.1
,
NP_001274678.1
,
NP_001274673.1
,
NP_001274671.1
,
NP_001274674.1
,
NP_001274677.1
,
NP_001274679.1
,
NP_001274672.1
ZINC - World Drugs
FDFT_HUMAN
Guide to Pharmacology - Targets
645
OpenTargets
ENSG00000079459
ZINC - FDA approved
FDFT_HUMAN
ZINC - Substances
FDFT_HUMAN
ZINC target
P37268
PRO
P37268
PDB
3WEH
,
3Q2Z
,
6PYV
,
3Q30
,
3VJA
,
3WEI
,
6PYW
,
3WSA
,
3WC9
,
3WEF
,
3WCM
,
3WCF
,
3VJC
,
3WEG
,
3WCD
,
3VJB
,
3WCI
,
3ASX
,
3WCH
,
6PYJ
,
3WCL
,
3WEJ
,
6PZ5
,
3LEE
,
3VJ9
,
3V66
,
3WEK
,
3WCJ
,
1EZF
,
3VJ8
ZINC - Investigational
FDFT_HUMAN
IntEnz
2.5.1.21
HPA
ENSG00000079459-FDFT1
GeneCards
P37268
Ensembl
ENSP00000496723
,
ENSG00000284967
,
ENST00000622850
,
ENST00000647178
,
ENSG00000079459
,
ENST00000647069
,
ENST00000220584
,
ENSP00000432331
,
ENST00000530664
,
ENSP00000390367
,
ENST00000528812
,
ENSP00000431649
,
ENSP00000431749
,
ENST00000528643
,
ENSP00000495060
,
ENST00000443614
,
ENSP00000220584
,
ENST00000615631
,
ENSP00000484122
,
ENSP00000481481
Pharos - Targets
P37268
Orphanet
24533
ZINC - Predictions - Purchasable
FDFT_HUMAN
HMDB Protein
HMDBP00260
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:O75503 CLN5
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:P04233-2 CD74
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:O43889-2 CREB3
0.556
3
UniProt:Q96RD7 PANX1
1
PANX1 [plasma membrane]
(R-HSA-375344)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q6IBW4-4 NCAPH2
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
UniProt:Q9H1C4 UNC93B1
4
UNC93B1 [Golgi membrane]
(R-HSA-1679064)
UNC93B1 [endoplasmic reticulum membrane]
(R-HSA-1678930)
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
(R-HSA-9628866)
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
(R-HSA-9628869)
0.527
2
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