Reduction of presqualene diphosphate to form squalene

Stable Identifier
R-HSA-191402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the second step, FDFT catalyzes the reduction of presqualene diphosphate to squalene (Pandit et al. 2000).

Literature References
PubMed ID Title Journal Year
10896663 Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

Pandit, J, Danley, DE, Schulte, GK, Mazzalupo, S, Pauly, TA, Hayward, CM, Hamanaka, ES, Thompson, JF, Harwood HJ, Jr

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
farnesyl-diphosphate farnesyltransferase activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created