Two FPP molecules dimerize to form presqualene diphosphate

Stable Identifier
R-HSA-191405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Farnesyl diphosphate farnesyltransferase (FDFT; squalene synthase) catalyzes the reductive dimerization of two farnesyl diphosphate (FPP) molecules to form squalene. This happens in two distinct steps. The first step of dimerization forms presqualene diphosphate (Pandit et al. 2000).

Literature References
PubMed ID Title Journal Year
10896663 Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

Pandit, J, Danley, DE, Schulte, GK, Mazzalupo, S, Pauly, TA, Hayward, CM, Hamanaka, ES, Thompson, JF, Harwood HJ, Jr

J Biol Chem 2000
Participants
Input
Participant Of
Catalyst Activity
Catalyst Activity
Title
farnesyl-diphosphate farnesyltransferase activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created