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GGPS1 [cytosol]
Stable Identifier
R-HSA-191415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
geranylgeranyl pyrophosphate synthase 1, GGPP synthase, prenyltransferase, Dimethylallyl trans-transferase, dimethylallyltransferase, geranyl-diphosphate synthase
Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)
GGPS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95749 GGPS1
Gene Names
GGPS1
Chain
chain:1-300
Reference Genes
BioGPS Gene:9453 GGPS1
COSMIC (genes):GGPS1 GGPS1
CTD Gene:9453 GGPS1
dbSNP Gene:9453 GGPS1
ENSEMBL:ENSG00000152904 GGPS1
HGNC:4249 GGPS1
KEGG:hsa:9453 GGPS1
Monarch:9453 GGPS1
NCBI Gene:9453 GGPS1
OMIM:606982 GGPS1
UCSC:O95749 GGPS1
Reference Transcript
RefSeq:NM_001037277.1 GGPS1
Other Identifiers
11717983_a_at
11741231_a_at
11741232_a_at
16678954
202321_PM_at
202321_at
202322_PM_s_at
202322_s_at
2386398
2386399
2386400
2386401
2386402
2386403
2386404
2386405
2386406
2386410
2386412
2386413
2386414
2386415
2386416
2386417
35296_at
47657_at
62798_at
7910640
80140_at
85644_at
9453
A_14_P123801
A_23_P52189
A_33_P3258041
GE53510
GO:0003824
GO:0004161
GO:0004311
GO:0004337
GO:0004659
GO:0005515
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006720
GO:0008299
GO:0016740
GO:0030018
GO:0033384
GO:0033386
GO:0042802
GO:0045337
GO:0046872
GO:0048471
HMNXSV003023236
Hs.55498.0.S2_3p_at
ILMN_1692276
ILMN_2346856
PH_hs_0003638
TC01001944.hg
TC01005129.hg
g4758429_3p_a_at
Participates
as an output of
Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)
as a component of
GGPS1:3Mg2+ [cytosol] (Homo sapiens)
Inferred To
ggps1 [cytosol]
(Xenopus tropicalis)
qm [cytosol]
(Drosophila melanogaster)
GGPS1 [cytosol]
(Bos taurus)
GGPS1 [cytosol]
(Canis familiaris)
GGPS1 [cytosol]
(Dictyostelium discoideum)
GGPS1 [cytosol]
(Gallus gallus)
GGPS1 [cytosol]
(Mus musculus)
GGPS1 [cytosol]
(Rattus norvegicus)
GGPS1 [cytosol]
(Saccharomyces cerevisiae)
GGPS1 [cytosol]
(Sus scrofa)
Cross References
ZINC - World Drugs
GGPPS_HUMAN
Guide to Pharmacology - Targets
643
OpenTargets
ENSG00000152904
ENSEMBL
ENST00000488594
,
ENSP00000282841
,
ENSP00000418690
,
ENST00000391855
,
ENSP00000375728
,
ENST00000358966
,
ENSP00000351852
,
ENST00000282841
ZINC - FDA approved
GGPPS_HUMAN
ZINC - Substances
GGPPS_HUMAN
ZINC target
O95749
PRO
O95749
PDB
2Q80
,
6G32
,
6R4V
,
6C56
,
6G31
,
6C57
ZINC - Investigational
GGPPS_HUMAN
IntEnz
2.5.1.10
HPA
ENSG00000152904-GGPS1
Pharos - Targets
O95749
Orphanet
GGPS1
ZINC - Predictions - Purchasable
GGPPS_HUMAN
HMDB Protein
HMDBP00931
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95749 GGPS1
1
GGPS1 [cytosol]
(R-HSA-191415)
0.742
7
UniProt:O00244 ATOX1
1
ATOX1 [cytosol]
(R-HSA-3697884)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:O75386 TULP3
1
TULP3 [cilium]
(R-HSA-5610445)
0.527
2
UniProt:P18509 ADCYAP1
4
ADCYAP1(132-158) [extracellular region]
(R-HSA-420144)
ADCYAP1(82-129) [extracellular region]
(R-HSA-420254)
ADCYAP1(132-169) [extracellular region]
(R-HSA-420282)
ADCYAP1(2-742) [Golgi membrane]
(R-HSA-187679)
0.527
2
UniProt:Q12950 FOXD4
0.527
3
UniProt:Q9NZB2 F120A
0.527
2
UniProt:Q3SYB3 FX4L6
0.527
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.527
2
UniProt:Q96BR6 ZNF669
1
ZNF669 [nucleoplasm]
(R-HSA-2248869)
0.527
2
UniProt:B2RXF5 ZBT42
0.527
3
UniProt:Q86W54 SPA24
0.527
2
UniProt:Q17RF5 ODAPH
0.527
2
UniProt:Q86TJ2 TADA2B
1
TADA2B [nucleoplasm]
(R-HSA-3322963)
0.527
2
UniProt:P12724 RNASE3
2
RNASE3 [azurophil granule lumen]
(R-HSA-6799158)
RNASE3 [extracellular region]
(R-HSA-6803115)
0.527
2
UniProt:Q9H5V7 IKZF5
0.527
2
UniProt:A6NKD9 CC85C
0.527
2
UniProt:Q2TAM9 TUSC1
0.527
2
UniProt:Q6ZMY9 ZNF517
1
ZNF517 [nucleoplasm]
(R-HSA-1973869)
0.527
2
UniProt:Q9H7X3 ZNF696
1
ZNF696 [nucleoplasm]
(R-HSA-2454138)
0.527
2
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