Mevalonate-5-phosphate is further phosphorylated.

Stable Identifier
R-HSA-191422
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Mevalonate-5-phosphate is further phosphorylated.
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphomevalonate kinase (PMK) catalyzes the reversible, ATP-dependent phosphorylation of mevalonate-5-phosphate, producing mevalonate-5-pyrophosphate.
Literature References
PubMed ID Title Journal Year
14729858 Phosphomevalonate kinase is a cytosolic protein in humans

Koster, J, Tuyp, JJ, Wanders, RJA, Espeel, M, Waterham, HR, Hogenboom, S

J Lipid Res 2004
16519518 Phosphomevalonate kinase: functional investigation of the recombinant human enzyme

Herdendorf, TJ, Miziorko, HM

Biochemistry 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphomevalonate kinase activity of PMVK [cytosol]

Physical Entity
PMVK [cytosol] (Homo sapiens)
Activity
phosphomevalonate kinase activity (GO:0004631)
Orthologous Events
Mevalonate-5-phosphate is further phosphorylated. (Bos taurus)
Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)
Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)
Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)
Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)
Mevalonate-5-phosphate is further phosphorylated. (Gallus gallus)
Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)
Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)
Mevalonate-5-phosphate is further phosphorylated. (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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