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L1CAM [plasma membrane]
Stable Identifier
R-HSA-191465
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
L1, Neural cell adhesion molecule L1, CAML_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)
L1:Axonin-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)
L1:CNTN1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)
L1:ALCAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Heat-Stable Antigen binds L1 (Homo sapiens)
L1:HSA [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
L1 dimer binds Ankyrin (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of Y1229 in L1 (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1 (Y1229):L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of L1 with Laminin-1 (Homo sapiens)
L1:HNK-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:Laminin [plasma membrane] (Homo sapiens)
L1:HNK-1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of L1 with Neurocan (Homo sapiens)
L1:Neurocan [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds RanBPM (Homo sapiens)
L1:RanBPM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by EPHB2 (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Interaction of NUMB with L1 (Homo sapiens)
L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds to AP-2 Clathrin complex (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 trans-homophilic interaction (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Linkage of L1 with treadmilling F-actin (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by ERK (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by SRC (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Reinsertion of L1 into the plasma membrane (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Transport of L1 from C-domain to P-domain (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Transport of L1 into endosomes (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
L1 and NCAM1 engaged in cis-interaction (Homo sapiens)
L1:NCAM1 complex [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 binds NRP1 (Homo sapiens)
L1:NRP1 [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1 interaction with Integrins (Homo sapiens)
L1:Integrin complex [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1-EGFR trans-heterodimerization (Homo sapiens)
L1-EGFR trans-heterodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1-FGFR cis-heterodimerization (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
L1:FGFR1 [plasma membrane] (Homo sapiens)
L1 homodimer [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by CK-II (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Basigin interactions (Homo sapiens)
Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)
Basigin:Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
L1CAM [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32004 L1CAM
Gene Names
L1CAM, CAML1, MIC5
Chain
signal peptide:1-19, chain:20-1257
Reference Genes
BioGPS Gene:3897 L1CAM
COSMIC (genes):L1CAM L1CAM
CTD Gene:3897 L1CAM
dbSNP Gene:3897 L1CAM
ENSEMBL:ENSG00000198910 L1CAM
HGNC:6470 L1CAM
KEGG Gene (Homo sapiens):3897 L1CAM
Monarch:3897 L1CAM
NCBI Gene:3897 L1CAM
OMIM:308840 L1CAM
UCSC:P32004 L1CAM
Reference Transcript
RefSeq:NM_000425.4 L1CAM
RefSeq:NM_001278116.1 L1CAM
RefSeq:NM_024003.3 L1CAM
RefSeq:NM_001143963.2 L1CAM
Other Identifiers
0001940162
10896
11724578_at
11724579_a_at
17115271
204584_at
204585_s_at
38551_at
3897
4026799
4026800
4026801
4026804
4026805
4026806
4026807
4026808
4026809
4026810
4026811
4026812
4026814
4026815
4026816
4026817
4026820
4026821
4026822
4026824
4026825
4026826
4026827
4026828
4026829
4026830
4026832
4026834
4026835
4026838
4026839
4026841
8175871
A_23_P171324
A_24_P207995
A_33_P3374443
AAA36353
AAA59476
AAC14352
AAH25843
AAI26230
AAI36448
ABP88252
BC025843
BC126229
BC136447
CAA41576
CAA42508
CAA82564
CAB010896
CAB37831
CCDS14733
CCDS14734
CCDS48192
CH471172
E7EMY4
E7EPI4
E7EVM4
E9PHJ4
EAW72787
EF506611
ENSG00000198910
ENSP00000354712
ENSP00000355380
ENSP00000359072
ENSP00000359077
ENST00000361699
ENST00000361699.8
ENST00000361981
ENST00000361981.7
ENST00000370055
ENST00000370055.5
ENST00000370060
ENST00000370060.6
EntrezGene:3897
EntrezGene:L1CAM
g13435354_3p_a_at
GE62364
GO:0000902
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005623
GO:0005886
GO:0005925
GO:0006935
GO:0007155
GO:0007156
GO:0007160
GO:0007275
GO:0007399
GO:0007411
GO:0008046
GO:0008150
GO:0009986
GO:0016020
GO:0016021
GO:0016477
GO:0019904
GO:0030154
GO:0030424
GO:0030425
GO:0030426
GO:0031012
GO:0031175
GO:0040007
GO:0040011
GO:0042995
GO:0043025
GO:0044295
GO:0045773
GO:0048856
GO:0048870
GO:0050808
GO:0050900
GO:0061564
GO:0062023
H3BLW5
HGNC:6470
Hs.1757.0.S3_3p_at
ILMN_1739238
ILMN_2362341
IPR003598
IPR003599
IPR003961
IPR007110
IPR013098
IPR013783
IPR026966
IPR036116
IPR036179
L1CAM
L1CAM-201
L1CAM-202
L1CAM-203
L1CAM-205
M55271
M74387
M77640
MIM:303350
MIM:304100
MIM:307000
MIM:308840
NM_000425
NM_001143963
NM_001278116
NM_024003
NP_000416
NP_001137435
NP_001265045
NP_076493
PF00041
PF07679
PF13882
PF13927
PH_hs_0026029
SM00060
SM00408
SM00409
TC0X002307.hg
U52111
U52112
U52112_rna1_at
UPI000002A55F
UPI0000126E89
UPI00001AEDC0
X58775
X58776
X59847
Z29373
Participant Of
hasComponent
L1 homodimer [plasma membrane]
L1 trans-homodimer [plasma membrane]
L1-EGFR trans-heterodimer [plasma membrane]
L1:ALCAM [plasma membrane]
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle]
L1:AP-2 Clathrin complex [endosome]
L1:Axonin-1 [plasma membrane]
L1:clathrin-coated vesicle [plasma membrane]
L1:CNTN1 [plasma membrane]
L1:HNK-1 [plasma membrane]
L1:HSA [plasma membrane]
L1:Integrin complex [plasma membrane]
L1:NCAM1 complex [plasma membrane]
L1:Neurocan [plasma membrane]
L1:NRP1 [plasma membrane]
L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle]
L1:RanBPM [plasma membrane]
pL1 (Y1229):L1CAM [plasma membrane]
input
Cis-heterodimerization of L1 and Axonin-1
Cis-heterodimerization of L1 and Contactin-1/F3/F11
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN
Heat-Stable Antigen binds L1
Interaction of L1 with Neurocan
Interaction of NUMB with L1
L1 and NCAM1 engaged in cis-interaction
L1 binds NRP1
L1 binds RanBPM
L1 binds to AP-2 Clathrin complex
L1 interaction with Integrins
L1 trans-homophilic interaction
L1-EGFR trans-heterodimerization
Phosphorylation of L1 by CK-II
Phosphorylation of L1 by EPHB2
Phosphorylation of L1 by p90rsk
Phosphorylation of L1 by SRC
output
Dephosphorylation of pL1 (Y1176)
Reinsertion of L1 into the plasma membrane
hasMember
Mannose-carrying cell recognition molecules [plasma membrane]
Other forms of this molecule
p-S1181-L1CAM [plasma membrane]
p-S1204,S1248-L1CAM [plasma membrane]
p-S1152-L1CAM [plasma membrane]
p-Y-L1CAM [plasma membrane]
p-Y1176-L1CAM [plasma membrane]
p-Y1229-L1CAM [plasma membrane]
Inferred To
Ghost homologue of L1CAM [plasma membrane] (Caenorhabditis elegans)
Ghost homologue of L1CAM [plasma membrane] (Canis familiaris)
Ghost homologue of L1CAM [plasma membrane] (Danio rerio)
Ghost homologue of L1CAM [plasma membrane] (Dictyostelium discoideum)
Ghost homologue of L1CAM [plasma membrane] (Drosophila melanogaster)
Ghost homologue of L1CAM [plasma membrane] (Gallus gallus)
Ghost homologue of L1CAM [plasma membrane] (Saccharomyces cerevisiae)
Ghost homologue of L1CAM [plasma membrane] (Schizosaccharomyces pombe)
Ghost homologue of L1CAM [plasma membrane] (Sus scrofa)
Ghost homologue of L1CAM [plasma membrane] (Xenopus tropicalis)
L1CAM [plasma membrane] (Mus musculus)
L1CAM [plasma membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_001265045.1
,
NP_000416.1
,
NP_001137435.1
,
NP_076493.1
OpenTargets
ENSG00000198910
GeneCards
P32004
PRO
P32004
Orphanet
16330
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ganglioside GM1 [ChEBI:61048]
2
GM1 [external side of plasma membrane]
(R-ALL-8850300)
GM1 [lysosomal membrane]
(R-ALL-1605677)
0.556
3
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