Reactome | CTNNA1 [plasma membrane]

CTNNA1 [plasma membrane]

Stable Identifier

R-HSA-191735

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

alpha-catenin

Locations in the PathwayBrowser for interactor UniProt:P18206 VCL

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External Reference Information

External Reference

UniProt:P35221 CTNNA1

Gene Names

CTNNA1

Chain

initiator methionine:, chain:2-906

Reference Genes

BioGPS Gene:1495 CTNNA1

COSMIC (genes):CTNNA1 CTNNA1

CTD Gene:1495 CTNNA1

dbSNP Gene:1495 CTNNA1

ENSEMBL:ENSG00000044115 CTNNA1

ENSEMBL_homo_sapiens_GENE:ENSG00000044115.21 CTNNA1

HGNC:2509 CTNNA1

KEGG Gene (Homo sapiens):1495 CTNNA1

Monarch:1495 CTNNA1

NCBI Gene:1495 CTNNA1

OMIM:116805 CTNNA1

UCSC:P35221 CTNNA1

Reference Transcript

Other Identifiers

11727396_a_at

11727397_s_at

11749005_a_at

11749673_x_at

11750386_s_at

11754811_x_at

1495

1558214_PM_s_at

1558214_s_at

16989750

200764_PM_s_at

200764_s_at

200765_PM_x_at

200765_x_at

2069_s_at

2085_s_at

210844_PM_x_at

210844_x_at

2830955

2830961

2830964

2830965

2830975

2830976

2830979

2830980

2830981

2830982

2830997

2831000

2831001

2831002

2831007

2831012

2831013

2831014

2831015

2831017

2831018

2831020

2831024

2831028

2831029

2831030

2831031

2831032

2831033

2831034

2871777

2871778

41153_f_at

41154_r_at

41155_at

41156_g_at

73088_at

73090_g_at

73092_at

8108378

A_33_P3403418

GO:0001541

GO:0001669

GO:0003723

GO:0005198

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005915

GO:0005925

GO:0006915

GO:0007155

GO:0007163

GO:0007224

GO:0007229

GO:0007405

GO:0007406

GO:0008013

GO:0008092

GO:0008104

GO:0008584

GO:0012501

GO:0014070

GO:0014704

GO:0015629

GO:0016020

GO:0016264

GO:0016342

GO:0016477

GO:0016600

GO:0017166

GO:0022414

GO:0023052

GO:0030027

GO:0030054

GO:0030154

GO:0031103

GO:0031410

GO:0034330

GO:0042127

GO:0042475

GO:0042802

GO:0043066

GO:0043226

GO:0043231

GO:0043297

GO:0043627

GO:0044877

GO:0045295

GO:0045296

GO:0045880

GO:0048856

GO:0048870

GO:0051015

GO:0070161

GO:0071681

GO:0090136

GO:0097192

GO:0098609

GO:1900181

GO:2000146

GO:2001045

GO:2001240

GO:2001241

HMNXSV003053372

Hs.178452.0.S1_3p_a_at

Hs2.435812.1.S1_3p_s_at

ILMN_1804854

ILMN_2230902

U03100_at

g4503126_3p_x_at

Participates

as a component of

as an input of

Other forms of this molecule

CTNNA1 [cytosol]

Inferred To

CTNNA1 [plasma membrane] (Bos taurus)

CTNNA1 [plasma membrane] (Canis familiaris)

CTNNA1 [plasma membrane] (Gallus gallus)

CTNNA1 [plasma membrane] (Sus scrofa)

Ghost homologue of CTNNA1 [plasma membrane] (Rattus norvegicus)

Homologues of CTNNA1 [plasma membrane] (Drosophila melanogaster)

Spt [plasma membrane] (Drosophila melanogaster)

hmp-1 [plasma membrane] (Caenorhabditis elegans)

Ctnna1 [plasma membrane] (Mus musculus)

ctnna1 [plasma membrane] (Danio rerio)

ctnna1 [plasma membrane] (Xenopus tropicalis)

Sry-alpha [plasma membrane] (Drosophila melanogaster)

alpha-Cat [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001310916.1, NP_001277241.1, NP_001310911.1, NP_001310926.1, NP_001277238.1, NP_001310921.1, NP_001310924.1, NP_001310919.1, NP_001310920.1, NP_001310929.1, NP_001310925.1, NP_001310918.1, NP_001310912.1, NP_001277236.1, NP_001310913.1, NP_001310928.1, NP_001310923.1, NP_001310922.1, NP_001894.2, NP_001310917.1, NP_001310927.1, NP_001277239.1

OpenTargets

ENSG00000044115

GeneCards

P35221

HPA

ENSG00000044115-CTNNA1

Ensembl

ENSP00000304669, ENSG00000044115, ENST00000540387, ENST00000302763, ENSP00000438476

PRO

P35221

Pharos - Targets

P35221

Orphanet

23343

PDB

6V2P, 6UPV, 6V2O, 4IGG, 7UTJ, 4EHP, 1H6G

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.893	8
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.803	8
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.68	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.64	3
UniProt:P35221 CTNNA1	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.618	3
UniProt:Q5VT06 CE350			0.581	5
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.576	5
UniProt:P18206-2 VCL			0.558	2
UniProt:P0DTD8 NS7B			0.527	2
UniProt:P18206 VCL	8	VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL(95 kDa) [cytosol] (R-HSA-9861471) VCL [specific granule lumen] (R-HSA-6799711) VCL [secretory granule lumen] (R-HSA-6801010) VCL [extracellular region] (R-HSA-350736) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [cytosol] (R-HSA-350753)	0.527	2
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.519	2
UniProt:P51957 NEK4			0.508	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.499	3
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	3

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