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CTNNA1 [plasma membrane]
Stable Identifier
R-HSA-191735
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
alpha-catenin
Locations in the PathwayBrowser for interactor UniProt:P25963 NFKBIA
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
CTNNA1 [plasma membrane] (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
Regulation of CDH11 Expression and Function (Homo sapiens)
Regulation of CDH11 function (Homo sapiens)
CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)
CTNNA1 [plasma membrane] (Homo sapiens)
Regulation of CDH19 Expression and Function (Homo sapiens)
CDH19 associates with catenins (Homo sapiens)
CTNNA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35221 CTNNA1
Gene Names
CTNNA1
Chain
initiator methionine:, chain:2-906
Reference Genes
BioGPS Gene:1495 CTNNA1
COSMIC (genes):CTNNA1 CTNNA1
CTD Gene:1495 CTNNA1
dbSNP Gene:1495 CTNNA1
ENSEMBL:ENSG00000044115 CTNNA1
ENSEMBL_homo_sapiens_GENE:ENSG00000044115.21 CTNNA1
HGNC:2509 CTNNA1
KEGG Gene (Homo sapiens):1495 CTNNA1
Monarch:1495 CTNNA1
NCBI Gene:1495 CTNNA1
OMIM:116805 CTNNA1
UCSC:P35221 CTNNA1
Reference Transcript
RefSeq:NM_001323998.1 CTNNA1
RefSeq:NM_001290309.2 CTNNA1
RefSeq:NM_001323983.1 CTNNA1
RefSeq:NM_001323992.1 CTNNA1
RefSeq:NM_001323999.1 CTNNA1
RefSeq:NM_001323993.1 CTNNA1
RefSeq:NM_001323984.1 CTNNA1
RefSeq:NM_001324000.1 CTNNA1
RefSeq:NM_001290310.2 CTNNA1
RefSeq:NM_001323994.1 CTNNA1
RefSeq:NM_001323987.1 CTNNA1
RefSeq:NM_001903.4 CTNNA1
RefSeq:NM_001290312.1 CTNNA1
RefSeq:NM_001323995.1 CTNNA1
RefSeq:NM_001323988.1 CTNNA1
RefSeq:NM_001323989.1 CTNNA1
RefSeq:NM_001323996.1 CTNNA1
RefSeq:NM_001323990.1 CTNNA1
RefSeq:NM_001323982.1 CTNNA1
RefSeq:NM_001323997.1 CTNNA1
RefSeq:NM_001290307.2 CTNNA1
RefSeq:NM_001323991.1 CTNNA1
Other Identifiers
11727396_a_at
11727397_s_at
11749005_a_at
11749673_x_at
11750386_s_at
11754811_x_at
1495
1558214_PM_s_at
1558214_s_at
16989750
200764_PM_s_at
200764_s_at
200765_PM_x_at
200765_x_at
2069_s_at
2085_s_at
210844_PM_x_at
210844_x_at
2830955
2830961
2830964
2830965
2830975
2830976
2830979
2830980
2830981
2830982
2830997
2831000
2831001
2831002
2831007
2831012
2831013
2831014
2831015
2831017
2831018
2831020
2831024
2831028
2831029
2831030
2831031
2831032
2831033
2831034
2871777
2871778
41153_f_at
41154_r_at
41155_at
41156_g_at
73088_at
73090_g_at
73092_at
8108378
A_33_P3403418
GO:0001541
GO:0001669
GO:0003723
GO:0005198
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005915
GO:0005925
GO:0006915
GO:0007155
GO:0007163
GO:0007224
GO:0007229
GO:0007405
GO:0007406
GO:0008013
GO:0008092
GO:0008104
GO:0008584
GO:0012501
GO:0014070
GO:0014704
GO:0015629
GO:0016020
GO:0016264
GO:0016342
GO:0016477
GO:0016600
GO:0017166
GO:0022414
GO:0023052
GO:0030027
GO:0030054
GO:0030154
GO:0031103
GO:0031410
GO:0034330
GO:0042127
GO:0042475
GO:0042802
GO:0043066
GO:0043226
GO:0043231
GO:0043297
GO:0043627
GO:0044877
GO:0045295
GO:0045296
GO:0045880
GO:0048856
GO:0048870
GO:0051015
GO:0070161
GO:0071681
GO:0090136
GO:0097192
GO:0098609
GO:1900181
GO:2000146
GO:2001045
GO:2001240
GO:2001241
HMNXSV003053372
Hs.178452.0.S1_3p_a_at
Hs2.435812.1.S1_3p_s_at
ILMN_1804854
ILMN_2230902
U03100_at
g4503126_3p_x_at
Participates
as a component of
p-S665-VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Homo sapiens)
Cadherin:Catenin complex [plasma membrane] (Homo sapiens)
CDH19:CTNDD1:CTNNB1/JUP:CTNNA1 [plasma membrane] (Homo sapiens)
CDH8:CTNDD1:CTNNB1/JUP:CTNNA1 [plasma membrane] (Homo sapiens)
CDH24:CTNDD1:CTNNB1/JUP:CTNNA1 [plasma membrane] (Homo sapiens)
CDH11:CTNND1:CTNNB1:CTNNA1 [plasma membrane] (Homo sapiens)
CDH11:CTNND1:JUP:CTNNA1 [plasma membrane] (Homo sapiens)
as an input of
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
CDH19 associates with catenins (Homo sapiens)
CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)
Other forms of this molecule
CTNNA1 [cytosol]
Inferred To
CTNNA1 [plasma membrane]
(Bos taurus)
CTNNA1 [plasma membrane]
(Canis familiaris)
CTNNA1 [plasma membrane]
(Gallus gallus)
CTNNA1 [plasma membrane]
(Sus scrofa)
Ghost homologue of CTNNA1 [plasma membrane]
(Rattus norvegicus)
Homologues of CTNNA1 [plasma membrane]
(Drosophila melanogaster)
Spt [plasma membrane]
(Drosophila melanogaster)
hmp-1 [plasma membrane]
(Caenorhabditis elegans)
Ctnna1 [plasma membrane]
(Mus musculus)
ctnna1 [plasma membrane]
(Danio rerio)
ctnna1 [plasma membrane]
(Xenopus tropicalis)
Sry-alpha [plasma membrane]
(Drosophila melanogaster)
alpha-Cat [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001310916.1
,
NP_001277241.1
,
NP_001310911.1
,
NP_001310926.1
,
NP_001277238.1
,
NP_001310921.1
,
NP_001310924.1
,
NP_001310919.1
,
NP_001310920.1
,
NP_001310929.1
,
NP_001310925.1
,
NP_001310918.1
,
NP_001310912.1
,
NP_001277236.1
,
NP_001310913.1
,
NP_001310928.1
,
NP_001310923.1
,
NP_001310922.1
,
NP_001894.2
,
NP_001310917.1
,
NP_001310927.1
,
NP_001277239.1
OpenTargets
ENSG00000044115
GeneCards
P35221
HPA
ENSG00000044115-CTNNA1
Ensembl
ENSP00000304669
,
ENSG00000044115
,
ENST00000540387
,
ENST00000302763
,
ENSP00000438476
PRO
P35221
Pharos - Targets
P35221
Orphanet
23343
PDB
6V2P
,
6UPV
,
6V2O
,
4IGG
,
7UTJ
,
4EHP
,
1H6G
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.893
8
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.803
8
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.68
5
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.64
3
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.618
3
UniProt:Q5VT06 CE350
0.581
5
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.576
5
UniProt:P18206-2 VCL
0.558
2
UniProt:P0DTD8 NS7B
0.527
2
UniProt:P18206 VCL
8
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713472)
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713480)
VCL(95 kDa) [cytosol]
(R-HSA-9861471)
VCL [specific granule lumen]
(R-HSA-6799711)
VCL [secretory granule lumen]
(R-HSA-6801010)
VCL [extracellular region]
(R-HSA-350736)
VCL [ficolin-1-rich granule lumen]
(R-HSA-6800985)
VCL [cytosol]
(R-HSA-350753)
0.527
2
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.519
2
UniProt:P51957 NEK4
0.508
2
UniProt:Q15599 NHRF2
0.508
2
UniProt:Q9H8V3 ECT2
1
ECT2 [cytosol]
(R-HSA-195036)
0.499
3
UniProt:Q9H0H5 RACGAP1
1
RACGAP1 [cytosol]
(R-HSA-195122)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.483
3
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