CHIP (STUB1) mediates ubiquitination of ERBB2

Stable Identifier
R-HSA-1918092
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CHIP (STUB1) mediates ubiquitination of ERBB2
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E3 ubiquitin ligase CHIP (STUB1) mediates ERBB2 ubiquitination by associating with the ERBB2 indirectly, through the chaperone protein HSP90. CHIP (STUB1) ubiquitinates both ERBB2 and HSP90, leading to their proteasome-dependent degradation. Ubiquitination of ERBB2 by CHIP (STUB1) is independent of ERBB2 activation.
Literature References
PubMed ID Title Journal Year
12239347 Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Mimnaugh, E, Yuan, X, Neckers, LM, Marcu, M, Xu, W, Patterson, C

Proc Natl Acad Sci U S A 2002
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Output
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Catalyst Activity

ubiquitin-protein transferase activity of STUB1 [cytosol]

Physical Entity
STUB1 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-02)
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