CUL5 mediates ubiquitination of ERBB2

Stable Identifier
R-HSA-1918095
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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E3 ubiquitin ligase Cullin-5 (CUL5) is recruited to the ERBB2 site at the plasma membrane and ubiquitinates ERBB2 in an HSP90-dependent way, targeting it for degradation. Ubiquitination of ERBB2 by CUL5 appears to be independent of CUL5 adaptor proteins ElonginB and ElonginC.

Literature References
PubMed ID Title Journal Year
19933325 Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

Ehrlich, ES, Wang, T, Luo, K, Xiao, Z, Niewiadomska, AM, Martinez, T, Xu, W, Neckers, LM, Yu, XF

Proc Natl Acad Sci U S A 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of CUL5 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created