snRNP nuclear import and release

Stable Identifier
R-HSA-191830
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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A properly assembled Sm core and the m3G cap structure are prerequisites for small nuclear ribonucleoprotein (snRNP) import into the nucleus. Once imported into the nucleus, the snRNPs are initially concentrated in Cajal bodies (CBs), where there is further processing of the snRNAs plus binding of additional proteins, from CRBs they transit to "speckles", from where they are engaged for pre-mRNA splicing. The SMN complexes in the nucleus are found throughout the nucleoplasm but are particularly concentrated in Gems, the "twins" of the snRNP-rich CBs.

Literature References
PubMed ID Title Journal Year
10531003 Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway

Sleeman, JE, Lamond, AI

Curr Biol 1999
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This event is regulated
Orthologous Events
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