Reactome | GEMIN4 [cytosol]

GEMIN4 [cytosol]

Stable Identifier

R-HSA-191836

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gemin 4

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 modulates host translation machinery (Homo sapiens)
        
        snRNP complex assembly (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN4 [cytosol] (Homo sapiens)
        
        Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P57678 GEMIN4

Gene Names

GEMIN4

Chain

chain:1-1058

Reference Genes

BioGPS Gene:50628 GEMIN4

COSMIC (genes):GEMIN4 GEMIN4

CTD Gene:50628 GEMIN4

dbSNP Gene:50628 GEMIN4

ENSEMBL:ENSG00000179409 GEMIN4

HGNC:15717 GEMIN4

KEGG:hsa:50628 GEMIN4

Monarch:50628 GEMIN4

NCBI Gene:50628 GEMIN4

OMIM:606969 GEMIN4

UCSC:P57678 GEMIN4

Reference Transcript

RefSeq:NM_015721.3 GEMIN4

Other Identifiers

11733935_a_at

11751366_a_at

16839254

205527_PM_s_at

205527_s_at

217099_PM_s_at

217099_s_at

33744_at

3739813

3739814

3739815

3739816

3739817

3739818

3739819

3739820

3739821

3739822

3739823

3739824

50628

8010946

A_23_P66867

GE79522

GO:0000387

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006397

GO:0008380

GO:0015030

GO:0016020

GO:0016071

GO:0016604

GO:0030532

GO:0032797

GO:0034719

GO:0043021

GO:0070062

GO:0097504

HMNXSV003014594

Hs.19614.1.S1_3p_s_at

ILMN_1770206

PH_hs_0015622

TC17000967.hg

Participates

as a component of

SMN complex [cytosol] (Homo sapiens)

Other forms of this molecule

GEMIN4 [nucleoplasm]

Inferred To

GEMIN4 [cytosol] (Bos taurus)

GEMIN4 [cytosol] (Canis familiaris)

GEMIN4 [cytosol] (Gallus gallus)

GEMIN4 [cytosol] (Sus scrofa)

Ghost homologue of GEMIN4 [cytosol] (Caenorhabditis elegans)

Ghost homologue of GEMIN4 [cytosol] (Dictyostelium discoideum)

Ghost homologue of GEMIN4 [cytosol] (Rattus norvegicus)

Ghost homologue of GEMIN4 [cytosol] (Xenopus tropicalis)

gemin4 [cytosol] (Danio rerio)

Gemin4 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_056536.2

ENSEMBL

ENST00000319004, ENSG00000179409, ENSP00000321706

OpenTargets

ENSG00000179409

GeneCards

GEMIN4

HPA

ENSG00000179409-GEMIN4

PRO

P57678

Pharos - Targets

P57678

GlyGen

P57678

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.845	6
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.725	5
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	5
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P62317	2	Snrpd2 [nucleoplasm] (R-MMU-71901) Snrpd2 [cytosol] (R-MMU-191810)	0.544	2
UniProt:P62315	3	Snrpd1 [nucleoplasm] (R-MMU-192215) Snrpd1 [cytosol] (R-MMU-191890) Snrpd1 [cytosol] (R-MMU-192217)	0.544	2
UniProt:P62303	2	SNRPE [nucleoplasm] (R-GGA-71905) SNRPE [cytosol] (R-GGA-191782)	0.544	2
UniProt:P62320	3	Snrpd3 [nucleoplasm] (R-MMU-71903) Snrpd3 [nucleoplasm] (R-MMU-192219) Snrpd3 [cytosol] (R-MMU-191781)	0.544	2
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.527	3
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	3