CYP7B1 7-hydroxylates 25OH-CHOL

Stable Identifier
R-HSA-192065
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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CYP7B1 7-hydroxylates 25OH-CHOL
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25-hydroxycholesterol (25OH-CHOL) is 7alpha-hydroxylated to cholest-5-ene-3beta,7alpha,25-triol (CHOL3b,7a,25TRIOL) by CYP7B1 (cytochrome P450 7B1) (Wu et al. 1999).
Literature References
PubMed ID Title Journal Year
10588945 Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1

Javitt, NB, Martin, KO, Wu, Z, Chiang, JY

J Lipid Res 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
oxysterol 7-alpha-hydroxylase activity (GO:0008396)
This event is regulated
Negatively by
Regulator
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
Orthologous Events
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2007-01-26)
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