4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

Stable Identifier
R-HSA-192067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
4-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+
ReviewStatus
5/5
Locations in the PathwayBrowser
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4-Cholesten-7alpha, 12alpha-diol-3-one and NADPH + H+ react to form 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+. This reaction is catalyzed by AKR1D1 (3-oxo-5-beta-steroid 4-dehydrogenase). AKR1D1 is localized to the cytosol, and in the course of the reaction its steroid substrate moves from the endoplasmic reticulum membrane to the cytosol. It is unclear whether this translocation results simply from its increased hydrophilicity or is mediated by the enzyme or another transport protein (Russell 2003).
Literature References
PubMed ID Title Journal Year
7508385 Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

Okuda, K, Kondo, KH, Bjorkhem, I, Setoguchi, Y, Kai, MH, Sjoblom, P, Eggertsen, G, Setoguchi, T

Eur J Biochem 1994
Participants
Participates
Catalyst Activity

aldo-keto reductase (NADP) activity of AKR1D1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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