25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)

Stable Identifier
R-HSA-192335
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
25(S) THCA-CoA + O2 => THCA-CoA + H2O2
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25(S) THCA-CoA and O2 react to form 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) and H2O2. This dehydrogenation reaction occurs in the peroxisomal matrix. It is catalyzed by the FAD-containing peroxisomal enzyme branched chain acyl-CoA oxidase (ACOX2). The enzyme transfers electrons to molecular oxygen and hydrogen peroxide is produced as a byproduct.

Literature References
PubMed ID Title Journal Year
8387517 The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney

Vanhove, GF, Van Veldhoven, PP, Fransen, M, Denis, S, Eyssen, HJ, Wanders, RJ, Mannaerts, GP

J Biol Chem 1993
8943006 Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome

Baumgart, E, Vanhooren, JC, Fransen, M, Marynen, P, Puype, M, Vandekerckhove, J, Leunissen, JA, Fahimi, HD, Mannaerts, GP, Van Veldhoven, PP

Proc Natl Acad Sci U S A 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acyl-CoA oxidase activity of ACOX2:FAD [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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