Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

Stable Identifier
R-HSA-192341
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
ReviewStatus
5/5
Locations in the PathwayBrowser
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA and CoASH react to form choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA. This reaction, in the peroxisomal matrix, is catalyzed by peroxisomal thiolase 2 (sterol carrier protein 2).
Literature References
PubMed ID Title Journal Year
10706581 Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method.

van Berkel, E, Denis, S, Wanders, RJA, Dacremont, G, Ferdinandusse, S

J Lipid Res 2000
1703300 Cloning and expression of a cDNA encoding human sterol carrier protein 2

Billheimer, JT, Rennert, H, Kallen, CB, Strauss JF, 3rd, Babalola, GO, Yamamoto, R

Proc Natl Acad Sci U S A 1991
Participants
Participates
Catalyst Activity

propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2-1 [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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