Reactome | IPO5 [nucleoplasm]

IPO5 [nucleoplasm]

Stable Identifier

R-HSA-192675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Importin beta-3, Ran binding protein-5

Locations in the PathwayBrowser for interactor UniProt:P18124 RPL7

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        vRNP Assembly (Homo sapiens)
        
        Viral Polymerase Assembly (Homo sapiens)
        
        IPO5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00410 IPO5

Gene Names

IPO5, KPNB3, RANBP5

Chain

initiator methionine:, chain:2-1097

Reference Genes

BioGPS Gene:3843 IPO5

COSMIC (genes):IPO5 IPO5

CTD Gene:3843 IPO5

dbSNP Gene:3843 IPO5

ENSEMBL:ENSG00000065150 IPO5

ENSEMBL_homo_sapiens_GENE:ENSG00000065150.21 IPO5

HGNC:6402 IPO5

KEGG Gene (Homo sapiens):3843 IPO5

Monarch:3843 IPO5

NCBI Gene:3843 IPO5

OMIM:602008 IPO5

UCSC:O00410 IPO5

Reference Transcript

Other Identifiers

11718105_s_at

11718106_s_at

11718107_a_at

211952_PM_at

211952_at

211953_3p_s_at

211953_PM_s_at

211953_s_at

211954_PM_s_at

211954_s_at

211955_PM_at

211955_at

3459007

3497794

3497796

3497797

3497798

3497800

3497801

3497803

3497804

3497805

3497808

3497809

3497810

3497811

3497812

3497814

3497815

3497817

3497818

3497820

3497821

3497822

3497823

3497824

3497826

3497827

3497828

3497829

3497830

3497833

3497835

3497836

3497838

3497839

3497840

3497841

3497844

3497847

3497848

3497849

3497850

3497851

3843

39028_at

44108_at

7969703

87848_s_at

A_14_P127826

A_23_P205007

A_24_P99071

GE60259

GO:0002376

GO:0002753

GO:0003723

GO:0005095

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005730

GO:0005737

GO:0005794

GO:0005829

GO:0006606

GO:0006607

GO:0006610

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0016020

GO:0023052

GO:0031267

GO:0031965

GO:0036211

GO:0042307

GO:0043226

GO:0045736

GO:0061608

GO:0071230

GO:0098542

GO:0098772

GO:0140104

HMNXSV003002934

Hs.113503.0.S1_3p_at

Hs.113503.0.S2_3p_a_at

Hs.113503.0.S3_3p_a_at

Hs.113503.0.S3_3p_at

Hs.113503.0.S4_3p_at

ILMN_2166384

PH_hs_0031543

TC13000343.hg

U72761_at

This entity regulates

Positively

Viral Polymerase Assembly (Homo sapiens)

Cross References

RefSeq

XP_005254110.1, XP_011519389.1, XP_016876051.1, XP_011519391.1, XP_005254109.1, XP_011519392.1, NP_002262.3, XP_011519390.1

OpenTargets

ENSG00000065150

HPA

ENSG00000065150-IPO5

GeneCards

O00410

Ensembl

ENST00000357602, ENSP00000261574, ENST00000651721, ENSP00000499125, ENSP00000418393, ENSP00000350219, ENST00000261574, ENSG00000065150, ENST00000490680

PRO

O00410

Pharos - Targets

O00410

HMDB Protein

HMDBP08466

PDB

6XTE, 6XU2

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.688	6
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.645	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.591	6
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.591	4
UniProt:P27958-PRO_0000037576			0.581	5
UniProt:P15659 PA			0.547	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [autophagosome membrane] (R-HSA-5683638) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [cytosol] (R-HSA-5679223)	0.544	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.544	2
UniProt:Q9UMY1 UTP16			0.527	2
UniProt:Q9UH62 ARMCX3	1	ARMCX3 [mitochondrial outer membrane] (R-HSA-9714514)	0.527	2
UniProt:Q8IXI2 RHOT1	2	RHOT1 [mitochondrial outer membrane] (R-HSA-3006728) PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139)	0.527	2
UniProt:Q8IXI1 RHOT2	1	RHOT2 [mitochondrial outer membrane] (R-HSA-3006730)	0.527	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	2
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:Q9Y3C1 NOP16			0.527	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q96GV9 MACIR			0.527	2
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	2
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.527	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.483	3

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