Viral mRNA Splicing (M, NS segments)

Stable Identifier
R-HSA-192781
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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The viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Alternately spliced mRNA transcribed from M and NS vRNA segments 7 and 8, producing the spliced mRNA for M2 and NEP/NS2, respectively, are thought to be coupled to the cellular splicing and export mechanisms (Lamb, 1980; Lamb, 1981; Chen, 2000; Li, 2001). As segments 7 and 8 each encode two proteins, splicing must be regulated allowing for alternative mRNAs, with the spliced products in the minority (approximately 10%). M1 splicing may be regulated by the viral polymerase and the cellular SR splicing protein SF2/ASF (Shih, 1995; Shih, 1996); while NS1 splicing appears to be regulated by the viral mRNA intrinsically (Alonso-Caplen, 1991; Valcarel, 1991).

Literature References
PubMed ID Title Journal Year
6246509 Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome

Lamb, RA, Choppin, PW, Chanock, RM, Lai, CJ

Proc Natl Acad Sci U S A 1980
11421366 The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo

Li, Y, Chen, ZY, Wang, W, Baker, CC, Krug, RM

RNA 2001
10920397 Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Chen, Z, Krug, RM

Trends Microbiol 2000
6945577 Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins

Lamb, RA, Lai, CJ, Choppin, PW

Proc Natl Acad Sci U S A 1981
Participants
Participant Of
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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