Reactome | HSP90AA1 [cytosol]

HSP90AA1 [cytosol]

Stable Identifier

R-HSA-192864

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSP90

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Locations in the PathwayBrowser for interactor UniProt:P26882

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External Reference Information

External Reference

UniProt:P07900 HSP90AA1

Gene Names

HSP90AA1, HSP90A, HSPC1, HSPCA

Chain

initiator methionine:1, chain:2-732

Reference Genes

BioGPS Gene:3320 HSP90AA1

COSMIC (genes):HSP90AA1 HSP90AA1

CTD Gene:3320 HSP90AA1

dbSNP Gene:3320 HSP90AA1

ENSEMBL:ENSG00000080824 HSP90AA1

HGNC:5253 HSP90AA1

KEGG Gene (Homo sapiens):3320 HSP90AA1

Monarch:3320 HSP90AA1

NCBI Gene:3320 HSP90AA1

OMIM:140571 HSP90AA1

UCSC:P07900 HSP90AA1

Reference Transcript

Other Identifiers

0005290524

11732996_at

11749934_s_at

11758308_s_at

16796829

1BYQ

1OSF

1UY6

1UY7

1UY8

1UY9

1UYC

1UYD

1UYE

1UYF

1UYG

1UYH

1UYI

1UYK

1UYL

1YC1

1YC3

1YC4

1YER

1YES

1YET

2058

210211_s_at

211968_s_at

211969_at

214328_s_at

2362304

2545387

2751645

2755868

2755880

2793561

2793563

2793567

2BSM

2BT0

2BUG

2BYH

2BYI

2BZ5

2C2L

2CCS

2CCT

2CCU

2FWY

2FWZ

2H55

2JJC

2K5B

2QF6

2QFO

2QG0

2QG2

2UWD

2VCI

2VCJ

2WI1

2WI2

2WI3

2WI4

2WI5

2WI6

2WI7

2XAB

2XDK

2XDL

2XDS

2XDU

2XDX

2XHR

2XHT

2XHX

2XJG

2XJJ

2XJX

2XK2

2YE2

2YE3

2YE4

2YE5

2YE6

2YE7

2YE8

2YE9

2YEA

2YEB

2YEC

2YED

2YEE

2YEF

2YEG

2YEH

2YEI

2YEJ

2YI0

2YI5

2YI6

2YI7

2YJW

2YJX

2YK2

2YK9

2YKB

2YKC

2YKE

2YKI

2YKJ

32316_s_at

3320

3367313

3367314

3367315

3367316

3367317

3367319

3367320

3367322

3367324

3367325

3367327

3367328

3367329

3580178

3580180

3580181

3580182

3580184

3580185

3580187

3580188

3580190

3580192

3580194

3580196

3580197

3580198

3580200

3580203

3580204

3580207

3580208

3580210

3580211

3580219

3580230

3B24

3B25

3B26

3B27

3B28

3BM9

3BMY

3D0B

3EKO

3EKR

3FT5

3FT8

3HEK

3HHU

3HYY

3HYZ

3HZ1

3HZ5

3INW

3INX

3K97

3K98

3K99

3MNR

3O0I

3OW6

3OWB

3OWD

3Q6M

3Q6N

3QDD

3QTF

3R4M

3R4N

3R4O

3R4P

3R91

3R92

3RKZ

3RLP

3RLQ

3RLR

3T0H

3T0Z

3T10

3T1K

3T2S

3TUH

3VHA

3VHC

3VHD

3WHA

3WQ9

4AIF

4AWO

4AWP

4AWQ

4B7P

4BQG

4BQJ

4CGQ

4CGU

4CGV

4CGW

4CWF

4CWN

4CWO

4CWP

4CWQ

4CWR

4CWS

4CWT

4EEH

4EFT

4EFU

4EGH

4EGI

4EGK

4FCP

4FCQ

4FCR

4HY6

4JQL

4L8Z

4L90

4L91

4L93

4L94

4LWE

4LWF

4LWG

4LWH

4LWI

4NH7

4NH8

4O04

4O05

4O07

4O09

4O0B

4R3M

4U93

4W7T

4XIP

4XIQ

4XIR

4XIT

4YKQ

4YKR

4YKT

4YKU

4YKW

4YKX

4YKY

4YKZ

5CF0

5FNC

5FND

5FNF

5GGZ

5J20

5J27

5J2V

5J2X

5J64

5J6L

5J6M

5J6N

5J80

5J82

5J86

5J8M

5J8U

5J9X

5LNY

5LNZ

5LO0

5LO1

5LO5

5LO6

5LQ9

5LR1

5LR7

5LRL

5LRZ

5LS1

5M4E

5M4H

5NYH

5NYI

5OCI

5OD7

5ODX

5T21

5VYY

5XQD

5XQE

5XR5

5XR9

5XRB

5XRE

5ZR3

6B99

6B9A

6CEO

6CYG

6CYH

6EI5

6EL5

6ELN

6ELO

6ELP

6EY8

6EY9

6EYA

6EYB

6F1N

6FCJ

6FDP

6GP4

6GP8

6GPF

6GPH

6GPO

6GPP

6GPR

6GPT

6GPW

6GPY

6GQ6

6GQR

6GQS

6GQU

6GR1

6GR3

6GR4

6GR5

7981335

A0A0U1RR69

A_23_P162866

A_23_P162874

A_33_P3665777

AAA36023

AAA63194

AAH00987

AAI21063

ABC40730

ACV87205

ADD71695

AJ890082

AJ890083

AK056446

AK291115

AK291607

AL133223

BAA13430

BAA13431

BAF83804

BAF84296

BAG51711

BC000987

BC121062

CAA30255

CAA33259

CAB002058

CAI64495

CAI64496

CCDS32160

CCDS9967

CH471061

D87666

DQ314871

EAW81765

EAW81766

EL52

ENSG00000080824

ENSP00000216281

ENSP00000335153

ENST00000216281

ENST00000216281.12

ENST00000334701

ENST00000334701.11

EntrezGene:3320

EntrezGene:HSP90AA1

g3287488_3p_a_at

G3V2J8

G3V592

GE59722

GO:0000086

GO:0000166

GO:0000278

GO:0000902

GO:0001934

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006259

GO:0006457

GO:0006464

GO:0006605

GO:0006810

GO:0006839

GO:0006898

GO:0006914

GO:0006950

GO:0006986

GO:0007004

GO:0007005

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0009056

GO:0009058

GO:0009408

GO:0009409

GO:0009986

GO:0010389

GO:0015031

GO:0016020

GO:0016192

GO:0016887

GO:0019221

GO:0019899

GO:0021955

GO:0022607

GO:0022618

GO:0023026

GO:0030010

GO:0030154

GO:0030234

GO:0030235

GO:0030911

GO:0031396

GO:0031410

GO:0031625

GO:0032273

GO:0032991

GO:0033138

GO:0034605

GO:0034641

GO:0034774

GO:0038096

GO:0038128

GO:0040007

GO:0042026

GO:0042470

GO:0042592

GO:0042623

GO:0042802

GO:0042803

GO:0042826

GO:0043025

GO:0043167

GO:0043202

GO:0043209

GO:0043226

GO:0043254

GO:0043312

GO:0043335

GO:0044183

GO:0044294

GO:0044295

GO:0045040

GO:0045429

GO:0046677

GO:0048010

GO:0048156

GO:0048471

GO:0048675

GO:0048856

GO:0050821

GO:0050999

GO:0051020

GO:0051082

GO:0051131

GO:0051186

GO:0051276

GO:0051897

GO:0051973

GO:0061024

GO:0061684

GO:0065003

GO:0070062

GO:0070182

GO:0071682

GO:0097110

GO:0097711

GO:0097718

GO:1900034

GO:1902949

GO:1903364

GO:1903827

GO:1904813

GO:1905323

GO:1990782

GQ149083

GQ472230

HGNC:5253

Hs.289088.4.A1_3p_at

Hs.289088.4.A2_3p_a_at

HSP90AA1

HSP90AA1-201

HSP90AA1-202

ILMN_1691097

ILMN_2373515

IPR001404

IPR003594

IPR019805

IPR020568

IPR020575

IPR036890

IPR037196

K9JA46

M27024

M30626

MIM:140571

NM_001017963

NM_005348

NP_001017963

NP_005339

PF00183

PF02518

PH_hs_0033549

PR00775

SM00387

TC14001526.hg

TC14002169.hg

UPI0000163B5F

UPI0000408144

X07270

X15183

X15183_at

XM_011536718

XP_011535020

Participant Of

hasComponent

hasMember

input

This entity regulates

Positively

Other forms of this molecule

HSP90AA1 [endocytic vesicle lumen]

HSP90AA1 [secretory granule lumen]

HSP90AA1 [extracellular region]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AA1 [plasma membrane]

HSP90AA1 [nucleoplasm]

HSP90AA1 [lysosomal lumen]

Inferred To

Hsp90aa1 [cytosol] (Mus musculus)

Hsp90aa1 [cytosol] (Rattus norvegicus)

hspD [cytosol] (Dictyostelium discoideum)

Ghost homologue of HSP90AA1 [cytosol] (Danio rerio)

Ghost homologue of HSP90AA1 [cytosol] (Sus scrofa)

Homologues of HSP90AA1 [cytosol] (Saccharomyces cerevisiae)

daf-21 [cytosol] (Caenorhabditis elegans)

hsp90aa1.1 [cytosol] (Xenopus tropicalis)

HSC82 [cytosol] (Saccharomyces cerevisiae)

HSP82 [cytosol] (Saccharomyces cerevisiae)

Hsp83 [cytosol] (Drosophila melanogaster)

HSP90AA1 [cytosol] (Bos taurus)

HSP90AA1 [cytosol] (Canis familiaris)

HSP90AA1 [cytosol] (Gallus gallus)

HSP90AA1 [cytosol] (Plasmodium falciparum)

swo1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_005339.3, NP_001017963.2

OpenTargets

ENSG00000080824

ZINC - Substances

HS90A_HUMAN

ZINC target

P07900

ZINC - Biogenic

HS90A_HUMAN

PRO

P07900

PDB

6ELN, 5LQ9, 4O05, 4XIT, 2BYH, 2XDX, 3R4P, 2YE3, 4YKZ, 3T0Z, 4W7T, 2YEA, 1UYF, 5OD7, 5M4E, 1UY7, 2CCT, 3QTF, 5LO1, 3RLP, 2XK2, 5XQE, 2YEF, 3Q6N, 5LNY, 4AWP, 4R3M, 5J80, 6GPH, 2UWD, 4LWG, 5GGZ, 3INX, 3TUH, 2YE7, 3B26, 1YER, 3OWD, 2YEI, 2QG2, 3HYY, 5J64, 6EYB, 6CEO, 4YKX, 5J6N, 3WQ9, 6GR1, 4XIR, 2YEC, 2WI5, 1UYL, 2XJG, 2YJX, 4NH7, 6B99, 1UY8, 2XDL, 4O09, 2BT0, 4CWQ, 3R4O, 3VHA, 6GQ6, 4L91, 3RLQ, 4CGW, 4EGH, 3BM9, 2QF6, 2BYI, 4CWS, 2YEG, 5LO0, 6GPO, 3OW6, 2VCJ, 5LR7, 4CGU, 4YKW, 4EFT, 5CF0, 2YKC, 2CCU, 5J2X, 6GR4, 6GP4, 2WI2, 6GPR, 4CGV, 1UYH, 6ELO, 3B27, 3HHU, 4NH8, 4FCQ, 5LRL, 3HYZ, 2XJJ, 3VHC, 4CGQ, 6GPP, 5J8M, 5XRB, 5NYI, 6EY8, 6GQR, 6F1N, 3VHD, 6GR3, 1YES, 2YED, 3FT5, 6CYH, 5J27, 5J6M, 4XIQ, 2XDS, 1UYG, 2XAB, 5OCI, 2FWY, 3HZ1, 4CWR, 2YK2, 2YE4, 2WI6, 2YI5, 4JQL, 4L90, 3T1K, 6GR5, 5J9X, 3FT8, 2WI3, 3B24, 1UYI, 3MNR, 2XHR, 1YC4, 1UY9, 3EKO, 3RLR, 4O04, 6GPW, 6B9A, 4EGK, 3HZ5, 2H55, 6FCJ, 3R4M, 6FDP, 5ODX, 4FCP, 2YKE, 2XHT, 3K99, 3B28, 4YKU, 3BMY, 4LWF, 2YEJ, 5J2V, 4YKT, 4B7P, 1UYD, 5ZR3, 2C2L, 3OWB, 2YE8, 5T21, 2BUG, 1YC1, 6EY9, 2FWZ, 2YEE, 6GQS, 5NYH, 4AWQ, 2QFO, 4CWN, 2WI7, 4LWI, 4BQG, 5LO6, 5XR9, 3K97, 6OLX, 5J86, 2WI1, 2YK9, 6EI5, 4HY6, 3R91, 3T10, 2BZ5, 6GPT, 6GP8, 6ELP, 4CWT, 2YE5, 4L94, 6CYG, 2YI6, 1BYQ, 4CWF, 4EEH, 5J20, 5LS1, 5XRE, 3B25, 4EFU, 2YE2, 4YKQ, 4O07, 2XDK, 1UYE, 2K5B, 1UY6, 6GPF, 1YC3, 2YJW, 2CCS, 3QDD, 2YKI, 2XHX, 3INW, 2XDU, 2WI4, 5M4H, 1UYK, 6N8X, 4EGI, 4U93, 5XR5, 5LNZ, 5J82, 1YET, 3Q6M, 4CWP, 4AWO, 2YE9, 5FNC, 4LWE, 3HEK, 3T0H, 4YKR, 3EKR, 3D0B, 5LR1, 4LWH, 2XJX, 6HHR, 3T2S, 5FNF, 2YI0, 2YKJ, 2YKB, 2QG0, 6GPY, 1OSF, 5XQD, 4FCR, 2YI7, 5LO5, 4L93, 4AIF, 5FND, 2VCI, 4L8Z, 4CWO, 3RKZ, 4YKY, 2YE6, 2YEH, 4O0B, 3K98, 4BQJ, 5LRZ, 6EL5, 6EYA, 2BSM, 3R4N, 3R92, 1UYC, 3O0I, 5J6L, 5VYY, 6GQU, 2JJC, 3WHA, 5J8U, 5XRD, 4XIP, 2YEB

ZINC - Investigational

HS90A_HUMAN

Target Pathogen

5b354852be737e166372e85d

GeneCards

P07900

HPA

ENSG00000080824-HSP90AA1

Ensembl

ENSG00000080824, ENST00000334701, ENSP00000335153, ENST00000216281, ENSP00000216281

ZINC - Predictions - Purchasable

HS90A_HUMAN

HMDB Protein

HMDBP02801

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.886	14
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.851	6
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.831	9
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.825	5
UniProt:Q9H6T3 RPAP3			0.806	6
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.794	11
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.778	7
UniProt:P04150 NR3C1	3	NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [nucleoplasm] (R-HSA-879837)	0.775	8
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.756	6
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.743	8
UniProt:P08107 HSP71			0.723	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.723	4
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [cytosol] (R-HSA-5618108)	0.723	8
UniProt:Q9UHD1 CHRD1			0.681	8
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.678	4
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.669	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.643	9
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.635	3
UniProt:O43318-2 MAP3K7			0.623	5
UniProt:P35467 S10A1			0.618	4
UniProt:Q8WVJ2 NUDC2			0.612	4
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.612	5
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.589	2
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.564	5
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.564	2
UniProt:Q9NYJ8 TAB2	5	TAB2 [endosome membrane] (R-HSA-450279) TAB2 [cytosol] (R-HSA-168117) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323) TAB2 [cytosol] (R-HSA-500563)	0.564	2
UniProt:Q14318 FKBP8	2	FKBP8 [mitochondrial outer membrane] (R-HSA-5696928) PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001)	0.564	7
UniProt:Q8IWD4 CC117			0.564	5
UniProt:O15111 CHUK	3	p-S176,S180-CHUK [cytosol] (R-HSA-177667) CHUK [cytosol] (R-HSA-168104) p-T23-CHUK [cytosol] (R-HSA-198615)	0.564	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.564	2
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.564	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.564	3
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.564	2
UniProt:Q15831 STK11	2	STK11 [nucleoplasm] (R-HSA-164119) STK11 [cytosol] (R-HSA-380954)	0.564	2
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.564	3
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.558	2
UniProt:O95433 AHSA1			0.547	4
UniProt:P07814 EPRS	1	EPRS [cytosol] (R-HSA-379649)	0.544	2
UniProt:Q9H1R3 MYLK2			0.527	8
UniProt:Q71U36 TUBA1A	9	Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408)	0.527	3
UniProt:Q15418 RPS6KA1	7	p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.527	3
UniProt:O95801 TTC4			0.527	4
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [cytosol] (R-HSA-380964) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.527	2
UniProt:Q15785 TOM34			0.527	4
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	3
UniProt:P11142 HSPA8	10	HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P26882	1	PPID [nucleoplasm] (R-BTA-8939168)	0.525	4
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.524	2
UniProt:Q9D1P4 CHRD1			0.508	3
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2