Reactome | HSP90AA1 [cytosol]

HSP90AA1 [cytosol]

Stable Identifier

R-HSA-192864

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSP90

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Locations in the PathwayBrowser for interactor UniProt:P26882

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External Reference Information

External Reference

UniProt:P07900 HSP90AA1

Gene Names

HSP90AA1, HSP90A, HSPC1, HSPCA

Chain

initiator methionine:1, chain:2-732

Reference Genes

BioGPS Gene:3320 HSP90AA1

COSMIC (genes):HSP90AA1 HSP90AA1

CTD Gene:3320 HSP90AA1

dbSNP Gene:3320 HSP90AA1

ENSEMBL:ENSG00000080824 HSP90AA1

HGNC:5253 HSP90AA1

KEGG Gene (Homo sapiens):3320 HSP90AA1

Monarch:3320 HSP90AA1

NCBI Gene:3320 HSP90AA1

OMIM:140571 HSP90AA1

UCSC:P07900 HSP90AA1

Reference Transcript

Other Identifiers

0005290524

11732996_at

11749934_s_at

11758308_s_at

16796829

210211_s_at

211968_s_at

211969_at

214328_s_at

2362304

2545387

2751645

2755868

2755880

2793561

2793563

2793567

32316_s_at

3320

3367313

3367314

3367315

3367316

3367317

3367319

3367320

3367322

3367324

3367325

3367327

3367328

3367329

3580178

3580180

3580181

3580182

3580184

3580185

3580187

3580188

3580190

3580192

3580194

3580196

3580197

3580198

3580200

3580203

3580204

3580207

3580208

3580210

3580211

3580219

3580230

7981335

A_23_P162866

A_23_P162874

A_33_P3665777

GE59722

GO:0000086

GO:0000166

GO:0000278

GO:0000902

GO:0001934

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006259

GO:0006457

GO:0006464

GO:0006605

GO:0006810

GO:0006839

GO:0006898

GO:0006914

GO:0006950

GO:0006986

GO:0007004

GO:0007005

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0009056

GO:0009058

GO:0009408

GO:0009409

GO:0009986

GO:0010389

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0016887

GO:0019221

GO:0019899

GO:0021955

GO:0022607

GO:0022618

GO:0023026

GO:0030010

GO:0030154

GO:0030234

GO:0030235

GO:0030911

GO:0031396

GO:0031410

GO:0031625

GO:0032273

GO:0032991

GO:0033138

GO:0034605

GO:0034641

GO:0034774

GO:0038096

GO:0038128

GO:0040007

GO:0042026

GO:0042470

GO:0042592

GO:0042802

GO:0042803

GO:0042826

GO:0043025

GO:0043167

GO:0043202

GO:0043209

GO:0043226

GO:0043254

GO:0043312

GO:0043335

GO:0044183

GO:0044294

GO:0044295

GO:0044403

GO:0045040

GO:0045429

GO:0046677

GO:0048010

GO:0048156

GO:0048471

GO:0048675

GO:0048856

GO:0050821

GO:0050999

GO:0051020

GO:0051082

GO:0051131

GO:0051276

GO:0051897

GO:0051973

GO:0061024

GO:0061684

GO:0065003

GO:0070062

GO:0070182

GO:0071682

GO:0097110

GO:0097711

GO:0097718

GO:1900034

GO:1902949

GO:1903364

GO:1903827

GO:1904813

GO:1905323

GO:1990782

Hs.289088.4.A1_3p_at

Hs.289088.4.A2_3p_a_at

ILMN_1691097

ILMN_2373515

PH_hs_0033549

TC14001526.hg

TC14002169.hg

X15183_at

g3287488_3p_a_at

Participant Of

hasComponent

hasMember

input

This entity regulates

Positively

Other forms of this molecule

HSP90AA1 [endocytic vesicle lumen]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AA1 [extracellular region]

HSP90AA1 [secretory granule lumen]

HSP90AA1 [plasma membrane]

HSP90AA1 [nucleoplasm]

HSP90AA1 [lysosomal lumen]

Inferred To

Hsp90aa1 [cytosol] (Mus musculus)

Hsp90aa1 [cytosol] (Rattus norvegicus)

hspD [cytosol] (Dictyostelium discoideum)

Ghost homologue of HSP90AA1 [cytosol] (Sus scrofa)

Homologues of HSP90AA1 [cytosol] (Saccharomyces cerevisiae)

adam33 [cytosol] (Xenopus tropicalis)

daf-21 [cytosol] (Caenorhabditis elegans)

HSC82 [cytosol] (Saccharomyces cerevisiae)

hsp90aa1.2 [cytosol] (Danio rerio)

HSP82 [cytosol] (Saccharomyces cerevisiae)

Hsp83 [cytosol] (Drosophila melanogaster)

HSP90AA1 [cytosol] (Canis familiaris)

HSP90AA1 [cytosol] (Gallus gallus)

HSP90AA1 [cytosol] (Plasmodium falciparum)

swo1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_005339.3, NP_001017963.2

OpenTargets

ENSG00000080824

ZINC - Substances

HS90A_HUMAN

ZINC - Biogenic

HS90A_HUMAN

ZINC target

P07900

PRO

P07900

PDB

4EGK, 5XRB, 3R4P, 5J27, 4R3M, 3RLP, 5LQ9, 6GR1, 5M4H, 6GQU, 4XIP, 4YKW, 5OCI, 2XHT, 3T2S, 2YEA, 3MNR, 3K97, 2BZ5, 3RLQ, 3INX, 2YEE, 3T1K, 2WI1, 4CWN, 4FCQ, 2CCS, 1BYQ, 4L90, 2WI4, 3K99, 4L8Z, 2XDK, 3D0B, 2YI5, 4BQJ, 4YKX, 2QFO, 5ZR3, 2FWZ, 3B26, 4CWO, 4O09, 3HZ1, 5LO6, 4NH7, 2WI7, 6GPH, 4NH8, 5FNC, 2BUG, 5CF0, 4O07, 6EI5, 4AIF, 5J6M, 2YEI, 2YJW, 5LS1, 2H55, 5T21, 1YES, 2YKB, 2YKJ, 6B9A, 5J6L, 6CYG, 5J8U, 1UY9, 4EGH, 2XJJ, 4LWH, 6B99, 6GPO, 5FNF, 1YC3, 2XDU, 3R4N, 1UYI, 5J8M, 4FCR, 4LWI, 4W7T, 4CGW, 1OSF, 6GR3, 2YI6, 4B7P, 2XHX, 1UYC, 3R91, 5OD7, 6GPW, 3B27, 4CWQ, 2YE7, 2BSM, 6ELN, 4L91, 4CGQ, 1YET, 3RLR, 2XJX, 4L93, 5J80, 2WI5, 2VCI, 2QG0, 2YJX, 4XIT, 2YEJ, 3FT5, 2YEF, 4O0B, 2YEB, 5J9X, 5NYH, 4CWP, 3O0I, 2JJC, 2YE2, 4XIR, 4YKY, 3WQ9, 4HY6, 5FND, 3B28, 3HHU, 1UYF, 3HZ5, 5J6N, 1UY6, 5LNY, 4YKZ, 4AWQ, 6CYH, 2XDX, 6GPR, 6GPP, 2YKC, 4U93, 1UYK, 5J2V, 4AWP, 3EKR, 1YC4, 6U9A, 4XIQ, 5XRD, 5VYY, 2K5B, 6U99, 2YE8, 2BT0, 2YEG, 2WI3, 4L94, 6GPY, 4CWR, 3FT8, 3QDD, 2YI7, 4LWG, 4YKR, 2YE5, 2XK2, 6ELO, 2YKI, 3OW6, 3R92, 3VHD, 1UYL, 5J86, 4CWS, 3OWB, 2XAB, 4YKQ, 5J82, 2YE3, 3HYY, 6GR5, 1UYD, 5XQE, 2YK2, 6FCJ, 5XQD, 6EY9, 5GGZ, 5NYI, 4JQL, 6EY8, 6GQ6, 6ELP, 1UYG, 2YEC, 3VHA, 2UWD, 1UY7, 2YE6, 2WI2, 5ODX, 5J2X, 3Q6M, 3TUH, 2CCT, 6N8X, 4LWE, 6GPT, 2XDL, 5LR7, 3B24, 4EEH, 6U9B, 6KSQ, 5LNZ, 6F1N, 5LR1, 5LO0, 6GP4, 5XRE, 2BYH, 3T0H, 6GR4, 2YKE, 6EL5, 6HHR, 5M4E, 3BMY, 6U98, 4YKU, 6FDP, 4EGI, 2FWY, 3R4O, 2C2L, 2YEH, 1YC1, 6CEO, 5J20, 5XR9, 3K98, 4AWO, 6GQS, 4CWT, 4YKT, 6GQR, 3EKO, 1UYE, 3HEK, 5XR5, 6OLX, 4FCP, 3B25, 2YE9, 5LRL, 3QTF, 4BQG, 3RKZ, 3HYZ, 3VHC, 2XJG, 4LWF, 3T10, 2CCU, 2YK9, 2XDS, 1UYH, 6GPF, 4O05, 3INW, 2YED, 4EFT, 3BM9, 4CWF, 5LO1, 2YE4, 2WI6, 2VCJ, 3WHA, 5LO5, 2QG2, 3T0Z, 3Q6N, 2YI0, 6EYB, 2XHR, 2QF6, 6GP8, 2BYI, 4CGV, 6EYA, 4O04, 4EFU, 5LRZ, 4CGU, 1YER, 5J64, 3R4M, 1UY8, 3OWD

ZINC - Investigational

HS90A_HUMAN

Target Pathogen

5b354852be737e166372e85d

HPA

ENSG00000080824-HSP90AA1

GeneCards

P07900

Ensembl

ENSG00000080824, ENSP00000216281, ENST00000334701, ENST00000216281, ENSP00000335153

ZINC - Predictions - Purchasable

HS90A_HUMAN

HMDB Protein

HMDBP02801

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.886	14
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.851	6
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.831	9
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.825	5
UniProt:Q9H6T3 RPAP3			0.806	6
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.794	11
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.778	7
UniProt:P04150 NR3C1	3	NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [nucleoplasm] (R-HSA-879837)	0.775	8
UniProt:Q15185 PTGES3	2	PTGES3 [cytosol] (R-HSA-265269) PTGES3 [nucleoplasm] (R-HSA-5082403)	0.756	6
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.743	8
UniProt:P08107 HSP71			0.723	4
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [cytosol] (R-HSA-5618108)	0.723	8
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.723	4
UniProt:Q9UHD1 CHRD1			0.681	8
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.678	4
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.669	4
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.666	5
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) p-T286-CAMK2A [plasma membrane] (R-HSA-432796) CAMK2A [cytosol] (R-HSA-4332329) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797)	0.666	5
UniProt:P17612 PRKACA	3	PRKACA [cytosol] (R-HSA-57844) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936)	0.666	4
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.643	9
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.635	3
UniProt:O43318-2 MAP3K7			0.623	5
UniProt:P35467 S10A1			0.618	4
UniProt:Q8WVJ2 NUDC2			0.612	4
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.612	5
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.61	4
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.589	2
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.564	5
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.564	2
UniProt:Q9NYJ8 TAB2	5	TAB2 [plasma membrane] (R-HSA-168116) TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [nucleoplasm] (R-HSA-1253323) TAB2 [cytosol] (R-HSA-500563)	0.564	2
UniProt:Q14318 FKBP8	2	FKBP8 [mitochondrial outer membrane] (R-HSA-5696928) PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001)	0.564	7
UniProt:Q8IWD4 CC117			0.564	5
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.564	3
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.564	3
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.564	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.564	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.564	2
UniProt:Q15831 STK11	2	STK11 [nucleoplasm] (R-HSA-164119) STK11 [cytosol] (R-HSA-380954)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.564	3
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.558	2
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779) CRMP1 [cytosol] (R-HSA-398120)	0.556	3
UniProt:Q92993-2 KAT5			0.556	3
UniProt:Q15438 CYTH1	2	CYTH1 [Golgi membrane] (R-HSA-8847825) CYTH1 [cytosol] (R-HSA-8847826)	0.556	3
UniProt:Q96LI6-3 Q96LI63			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q6QEF8-4 CORO6			0.556	3
UniProt:A0A0C4DFM3 A0A0C4DFM3			0.556	3
UniProt:Q9H6R7-2 Q9H6R72			0.556	3
UniProt:Q9BV29 CCD32			0.556	3
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.556	3
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:O95433 AHSA1			0.547	4
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.544	2
UniProt:Q9H1R3 MYLK2			0.527	8
UniProt:Q71U36 TUBA1A	9	Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408)	0.527	3
UniProt:Q15418 RPS6KA1	7	p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.527	3
UniProt:O95801 TTC4			0.527	4
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [cytosol] (R-HSA-380964) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.527	2
UniProt:Q15785 TOM34			0.527	4
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	3
UniProt:P26882 PPID			0.525	4
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.524	2
UniProt:Q9D1P4 CHRD1			0.508	3
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2

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