Reduction of androstenedione to testosterone

Stable Identifier
R-HSA-193064
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.
Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
In males, Lutropin (LH) stimulates testosterone production.

Literature References
PubMed ID Title Journal Year
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
8547185 Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition

Luu-The, V, Zhang, Y, Poirier, D, Labrie, F

J Steroid Biochem Mol Biol 1995
2197970 Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase

Luu-The, V, Labrie, C, Zhao, HF, Couet, J, Lachance, Y, Simard, J, Cote, J, Leblanc, G, Lagace, L, Berube, D, Gagne, R, Labrie, F

Ann N Y Acad Sci 1990
8075637 Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3

Geissler, WM, Davis, DL, Wu, L, Bradshaw, KD, Patel, S, Mendonca, BB, Elliston, KO, Wilson, JD, Russell, DW, Andersson, S

Nat Genet 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
testosterone dehydrogenase [NAD(P)] activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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