Reactome: A Curated Pathway Database

Reduction of androstenedione to testosterone

Stable Identifier
R-HSA-193064
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.
Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
In males, Lutropin (LH) stimulates testosterone production.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
testosterone dehydrogenase (NAD+) activity of HSD17B3-like Proteins [endoplasmic reticulum membrane] HSD17B3-like Proteins [endoplasmic reticulum membrane] testosterone dehydrogenase (NAD+) activity (0047035)
Orthologous Events
Cross References
Rhea