Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

Stable Identifier
R-HSA-193065
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
ReviewStatus
5/5
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22beta-hydroxycholesterol, NADPH + H+, and O2 react to form 20alpha,22beta-hydroxycholesterol, NADP+ and H2O, catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane.
Literature References
PubMed ID Title Journal Year
3024157 Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta

Miller, WL, Chung, BC, Voutilainen, R, Mohandas, TK, Matteson, KJ

Proc Natl Acad Sci U S A 1986
9578606 Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462

Downs, T, Tuckey, RC, Woods, ST, Triantopoulos, T, Sadleir, J, Headlam, MJ

Arch Biochem Biophys 1998
Participants
Participates
Catalyst Activity

cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]

Orthologous Events
Authored
Reviewed
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