Reactome: A Curated Pathway Database

CYP17A1 17-hydroxylates PREG

Stable Identifier
R-HSA-193068
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
Locations in the PathwayBrowser
Summation

Pregnenolone (PREG) and NADPH + H+ react to form 17alpha-hydroxypregnenolone (17aHPREG), NADP+, and H2O. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane, catalyzes this reaction.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane] CYP17A1 [endoplasmic reticulum membrane] steroid 17-alpha-monooxygenase activity (0004508)
Orthologous Events