Reactome: A Curated Pathway Database

CYP17A1 17-hydroxylates P4

Stable Identifier
R-HSA-193072
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
Locations in the PathwayBrowser
Summation

Progesterone (P4), NADPH + H+, and O2 react to form 17alpha-hydroxyprogesterone (17aHPROG), NADP+, and H2O. This reaction is catalyzed by steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane] CYP17A1 [endoplasmic reticulum membrane] steroid 17-alpha-monooxygenase activity (0004508)
Orthologous Events