Reactome: A Curated Pathway Database

DHA isomerizes to 4-Androstene3,17-dione

Stable Identifier
R-HSA-193073
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In this two-step reaction catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane, the 3-hydroxyl group of DHA is oxidized to a keto group and the double bond in the steroid nucleus is then isomerized from the five to the 4 position. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steroid delta-isomerase activity of HSD2B1 or HSD3B2 dimer [endoplasmic reticulum membrane] HSD2B1 or HSD3B2 dimer [endoplasmic reticulum membrane] steroid delta-isomerase activity (0004769)
Orthologous Events