Reactome | CYP17A1 cleaves 17aHPROG to ANDST

CYP17A1 cleaves 17aHPROG to ANDST

Stable Identifier

R-HSA-193099

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde

ReviewStatus

5/5

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17Alpha-hydroxyprogesterone (17aHPROG), NADPH + H+, and O2 react to form 4-Androstene-3, 17-dione (ANDST), NADP+, H2O, and acetaldehyde. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), which also catalyzes 17-alpha-hydroxylation, catalyzes this lyase reaction.

Literature References

PubMed ID	Title	Journal	Year
10406467	Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations Miller, WL, Auchus, RJ	Mol Endocrinol	1999