CYP19A1 hydroxylates TEST to EST17b

Stable Identifier
R-HSA-193143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Testosterone is converted to estradiol
ReviewStatus
5/5
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The conversion of testosterone to estradiol is catalyzed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane.
Literature References
PubMed ID Title Journal Year
8076586 Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis

Michael, MD, Bulun, SE, Graham-Lorence, S, Simpson, ER, Amarneh, B, Mendelson, CR, Fisher, CR, Mahendroo, MS, Ito, Y, Means, GD, Hinshelwood, MM, Kilgore, MW

Endocr Rev 1994
2171939 Structural and functional characterization of human aromatase P-450 gene

Yamamoto, Y, Toda, K, Sagara, Y, Kuribayashi, I, Terashima, M, Sumimoto, H, Kawamoto, T, Maeda, T, Yokoyama, Y, Mitsuuchi, Y

Eur J Biochem 1990
Participants
Participates
Catalyst Activity

steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]

Orthologous Events
Authored
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