Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

Stable Identifier
R-HSA-193533
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA + CoASH => chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
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3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA and CoASH react to form chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA. This reaction, in the peroxisomal matrix, is catalyzed by peroxisomal thiolase 2 (sterol carrier protein 2).

Literature References
PubMed ID Title Journal Year
1703300 Cloning and expression of a cDNA encoding human sterol carrier protein 2

Yamamoto, R, Kallen, CB, Babalola, GO, Rennert, H, Billheimer, JT, Strauss JF, 3rd

Proc Natl Acad Sci U S A 1991
10706581 Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method.

Ferdinandusse, S, Denis, S, van Berkel, E, Dacremont, G, Wanders, RJ

J Lipid Res 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2-1 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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