Reactome | CREBBP [nucleoplasm]

CREBBP [nucleoplasm]

Stable Identifier

R-HSA-193545

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CREB-binding protein, CBP_HUMAN, KAT3A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92793 CREBBP

Gene Names

CREBBP, CBP

Chain

initiator methionine:1, chain:2-2442

Reference Genes

BioGPS Gene:1387 CREBBP

COSMIC (genes):CREBBP CREBBP

CTD Gene:1387 CREBBP

dbSNP Gene:1387 CREBBP

ENSEMBL:ENSG00000005339 CREBBP

HGNC:2348 CREBBP

KEGG Gene (Homo sapiens):1387 CREBBP

Monarch:1387 CREBBP

NCBI Gene:1387 CREBBP

OMIM:600140 CREBBP

UCSC:Q92793 CREBBP

Reference Transcript

Other Identifiers

0005570717

11723893_s_at

11740647_a_at

11754200_a_at

11758105_s_at

11758635_s_at

1387

16823433

1JSP

1LIQ

1RDT

1WO3

1WO4

1WO5

1WO6

1WO7

1ZOQ

202160_at

211808_s_at

228177_at

2D82

2KJE

2KWF

2L84

2L85

2LXS

2LXT

2N1A

2RNY

33831_at

3677790

3677796

3677797

3677798

3677799

3677800

3677801

3677802

3677803

3677804

3677805

3677806

3677807

3677809

3677810

3677811

3677813

3677814

3677817

3677819

3677821

3677823

3677824

3677825

3677826

3677827

3677832

3677834

3677835

3677841

3677844

3677846

3677847

3677848

3677853

3677854

3677856

3677858

3677860

3677861

3677862

3677863

3677864

3677865

3677870

3677879

3677887

3677888

3677889

3677890

3904613

3DWY

3P1C

3P1D

3P1E

3P1F

3SVH

4212

46099_at

4A9K

4N3W

4N4F

4NR4

4NR5

4NR6

4NR7

4NYV

4NYW

4NYX

4OUF

4TQN

4TS8

4WHU

4YK0

55861

5CGP

5DBM

5EIC

5ENG

5EP7

5GH9

5H85

5I83

5I86

5I89

5I8B

5I8G

5J0D

5JEM

5KTU

5KTW

5KTX

5LPJ

5LPL

5MME

5MMG

5MPK

5MPN

5MPZ

5MQE

5MQG

5MQK

5NLK

5NRW

5NU3

5OWK

5SVH

5TB6

5W0E

5W0F

5W0L

5W0Q

5XXH

6ALB

6ALC

6AXQ

6AY3

6AY5

6DMK

6ES5

6ES6

6ES7

6FQO

6FQT

6FQU

6FR0

6FRF

7999044

A_23_P163850

A_24_P322025

A_24_P342279

A_33_P3240229

AAC51331

AAC51339

AAC51340

AAC51770

AB210043

BAE06125

CAB004212

CCDS10509

CCDS45399

CH471112

CREBBP

CREBBP-201

CREBBP-202

EAW85335

EAW85336

EAW85337

ENSG00000005339

ENSP00000262367

ENSP00000371502

ENST00000262367

ENST00000262367.9

ENST00000382070

ENST00000382070.7

EntrezGene:1387

EntrezGene:CREBBP

g4433815_3p_a_at

g4758055_3p_at

GE63206

GO:0000122

GO:0000123

GO:0000228

GO:0000790

GO:0000987

GO:0001085

GO:0001102

GO:0001666

GO:0002039

GO:0002223

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003684

GO:0003712

GO:0003713

GO:0003714

GO:0004402

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006355

GO:0006367

GO:0006464

GO:0006473

GO:0006629

GO:0006950

GO:0007165

GO:0007219

GO:0007221

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008589

GO:0009058

GO:0009790

GO:0016032

GO:0016407

GO:0016573

GO:0016604

GO:0016740

GO:0016746

GO:0018076

GO:0019216

GO:0022607

GO:0030154

GO:0030511

GO:0031648

GO:0032481

GO:0032991

GO:0034641

GO:0034644

GO:0042592

GO:0042733

GO:0042981

GO:0043167

GO:0043226

GO:0043426

GO:0044403

GO:0045637

GO:0045747

GO:0045893

GO:0045944

GO:0046872

GO:0048511

GO:0048856

GO:0051276

GO:0051604

GO:0061418

GO:0065003

GO:1900034

GO:1904837

HGNC:2348

HPA055861

Hs.283860.0.S1_3p_s_at

Hs.55153.0.A1_3p_at

I3L466

ILMN_1809583

ILMN_2293692

IPR000197

IPR000433

IPR001487

IPR003101

IPR009110

IPR010303

IPR013083

IPR013178

IPR014744

IPR018359

IPR031162

IPR035898

IPR036427

IPR036529

IPR037073

IPR038547

MIM:180849

MIM:600140

MIM:618332

NM_001079846

NM_004380

NP_001073315

NP_004371

PF00439

PF00569

PF02135

PF02172

PF06001

PF08214

PF09030

PH_hs_0023345

PR00503

SM00291

SM00297

SM00551

SM01250

TC16000823.hg

U47741

U85962

U89354

U89355

U89355_at

UPI0000000620

UPI0000EC7F51

XM_005255124

XM_005255125

XM_006720848

XM_011522381

XM_011522382

XM_017022944

XP_005255181

XP_005255182

XP_006720911

XP_011520683

XP_011520684

XP_016878433

Participant Of

hasComponent

input

output

hasMember

Other forms of this molecule

SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]

FOXO4-S-S-CREBBP [nucleoplasm]

Inferred To

CREBBP [nucleoplasm] (Bos taurus)

CREBBP [nucleoplasm] (Caenorhabditis elegans)

CREBBP [nucleoplasm] (Canis familiaris)

CREBBP [nucleoplasm] (Danio rerio)

CREBBP [nucleoplasm] (Drosophila melanogaster)

CREBBP [nucleoplasm] (Gallus gallus)

CREBBP [nucleoplasm] (Mus musculus)

CREBBP [nucleoplasm] (Rattus norvegicus)

CREBBP [nucleoplasm] (Sus scrofa)

CREBBP [nucleoplasm] (Xenopus tropicalis)

Homologues of CREBBP [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001073315.1, NP_004371.2

OpenTargets

ENSG00000005339

GeneCards

Q92793

ZINC - Substances

CBP_HUMAN

ZINC target

Q92793

PRO

Q92793

Orphanet

15801

ZINC - Predictions - Purchasable

CBP_HUMAN

HMDB Protein

HMDBP00014

PDB

5W0L, 4N3W, 1RDT, 2KJE, 5MME, 5MPN, 2LXT, 6FRF, 5W0Q, 2D82, 5EIC, 5I83, 5J0D, 5MMG, 5MPZ, 4TQN, 4YK0, 5LPJ, 2LXS, 2L85, 5XXH, 5I86, 5I89, 5LPL, 5JEM, 5MQE, 4A9K, 6ES5, 4NYX, 2RNY, 5MQG, 5ENG, 6ALB, 5NU3, 6ES6, 4NYW, 6DMK, 4NYV, 5SVH, 6ES7, 5NRW, 5I8B, 6ALC, 3DWY, 5MQK, 4NR7, 5TB6, 4NR6, 5I8G, 1JSP, 3P1F, 6AXQ, 3P1E, 5OWK, 5CGP, 6AY3, 5KTU, 4NR5, 5H85, 2N1A, 4NR4, 3P1D, 1WO7, 5KTW, 6AY5, 3P1C, 4WHU, 6FQO, 5W0E, 1WO5, 5KTX, 2KWF, 5NLK, 1WO6, 6FQT, 5EP7, 4N4F, 4TS8, 1LIQ, 5DBM, 1WO3, 1ZOQ, 5W0F, 6FR0, 2L84, 4OUF, 6FQU, 3SVH, 5MPK, 1WO4, 5GH9

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.911	11
UniProt:Q14653 IRF3	4	p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) IRF3 [cytosol] (R-HSA-166251)	0.899	10
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642)	0.757	6
UniProt:P03259 E1A			0.743	5
UniProt:P16220 CREB1	2	CREB1 [nucleoplasm] (R-HSA-52777) p-S133-CREB1 [nucleoplasm] (R-HSA-111910)	0.702	3
UniProt:Q15788 NCOA1	3	NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) SUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 [nucleoplasm] (R-HSA-442496)	0.669	4
UniProt:P03255 E1A			0.656	3
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.656	4
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.643	3
UniProt:Q13568 IRF5	1	IRF5 [cytosol] (R-HSA-1015676)	0.618	3
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.618	6
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.609	2
UniProt:P03259-2			0.602	3
UniProt:P55209 NP1L1			0.593	3
UniProt:P48551 IFNAR2			0.576	4
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.573	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.573	2
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.564	2
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.564	2
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032)	0.564	3
UniProt:Q12778 FOXO1	5	p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S215 FOXO1 [nucleoplasm] (R-HSA-5692651)	0.564	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.558	9
IntAct:EBI-15697717 P53K382AC			0.558	2
IntAct:EBI-1566585 IL8			0.527	2
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.527	12
ChEBI:83406 MS-417			0.525	2
UniProt:Q9UL17 TBX21			0.524	4
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.524	2
UniProt:P36956-1 SREBF1	5	SREBF1-1 [Golgi membrane] (R-HSA-1655753) SREBF1-1 [endoplasmic reticulum membrane] (R-HSA-1655757) SREBF1-1(1-530) [Golgi membrane] (R-HSA-1655718) SREBF1-1(1-490) [cytosol] (R-HSA-1655764) SREBF1-1(1-490) [nucleoplasm] (R-HSA-1655755)	0.499	3
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.499	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.499	3
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.499	2
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.499	2
UniProt:P36956-3 SREBF1	5	SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761) SREBF1-3 [nucleoplasm] (R-HSA-1655716) SREBF1-3 [Golgi membrane] (R-HSA-1655760) SREBF1-3 [Golgi membrane] (R-HSA-1655724) SREBF1-3 [cytosol] (R-HSA-1655721)	0.499	2