Reactome | CREBBP [nucleoplasm]

CREBBP [nucleoplasm]

Stable Identifier

R-HSA-193545

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CREB-binding protein, CBP_HUMAN, KAT3A

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92793 CREBBP

Gene Names

CREBBP, CBP

Chain

initiator methionine:, chain:2-2442

Reference Genes

BioGPS Gene:1387 CREBBP

COSMIC (genes):CREBBP CREBBP

CTD Gene:1387 CREBBP

dbSNP Gene:1387 CREBBP

ENSEMBL:ENSG00000005339 CREBBP

HGNC:2348 CREBBP

KEGG:hsa:1387 CREBBP

Monarch:1387 CREBBP

NCBI Gene:1387 CREBBP

OMIM:600140 CREBBP

UCSC:Q92793 CREBBP

Reference Transcript

Other Identifiers

11723893_s_at

11740647_a_at

11754200_a_at

11758105_s_at

11758635_s_at

1387

16823433

202160_PM_at

202160_at

211808_PM_s_at

211808_s_at

228177_PM_at

228177_at

33831_at

3677790

3677796

3677797

3677798

3677799

3677800

3677801

3677802

3677803

3677804

3677805

3677806

3677807

3677808

3677809

3677810

3677811

3677813

3677814

3677815

3677817

3677818

3677819

3677820

3677821

3677822

3677823

3677824

3677825

3677826

3677827

3677828

3677832

3677833

3677834

3677835

3677839

3677840

3677841

3677844

3677846

3677847

3677848

3677850

3677851

3677852

3677853

3677854

3677855

3677856

3677857

3677858

3677860

3677861

3677862

3677863

3677864

3677865

3677869

3677870

3677879

3677887

3677888

3677889

3677890

3904613

46099_at

7999044

A_23_P163850

A_24_P322025

A_24_P342279

A_33_P3240229

GE610347

GE63206

GO:0000122

GO:0000123

GO:0000785

GO:0001223

GO:0001666

GO:0002039

GO:0002223

GO:0002376

GO:0003677

GO:0003682

GO:0003684

GO:0003712

GO:0003713

GO:0003714

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006355

GO:0006473

GO:0007165

GO:0007249

GO:0008270

GO:0008589

GO:0016407

GO:0016479

GO:0016604

GO:0016740

GO:0016746

GO:0018076

GO:0030511

GO:0031490

GO:0031648

GO:0031669

GO:0034212

GO:0034644

GO:0042592

GO:0042733

GO:0043226

GO:0043426

GO:0043993

GO:0044017

GO:0044877

GO:0045893

GO:0045944

GO:0046872

GO:0048511

GO:0051604

GO:0060090

GO:0061629

GO:0061733

GO:0065003

GO:0120300

GO:0140096

GO:0140110

GO:0140297

GO:1900034

GO:1900182

GO:1905168

HMNXSV003016495

Hs.283860.0.S1_3p_s_at

Hs.55153.0.A1_3p_at

ILMN_1809583

ILMN_2293692

PH_hs_0023345

TC16000823.hg

U89355_at

g4433815_3p_a_at

g4758055_3p_at

Participates

as a component of

as an input of

as an output of

as a member of

This entity regulates

Negatively

HINT1 binds MITF-M (Homo sapiens)

Positively

BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)

Other forms of this molecule

CREBBP [cytosol]

FOXO4-S-S-CREBBP [nucleoplasm]

monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]

Inferred To

CREBBP [nucleoplasm] (Bos taurus)

CREBBP [nucleoplasm] (Caenorhabditis elegans)

CREBBP [nucleoplasm] (Canis familiaris)

CREBBP [nucleoplasm] (Gallus gallus)

CREBBP [nucleoplasm] (Mus musculus)

CREBBP [nucleoplasm] (Rattus norvegicus)

CREBBP [nucleoplasm] (Sus scrofa)

Ghost homologue of CREBBP [nucleoplasm] (Xenopus tropicalis)

nej [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001073315.1, NP_004371.2

Guide to Pharmacology - Targets

2734

OpenTargets

ENSG00000005339

ENSEMBL

ENSP00000371502, ENST00000382070, ENSP00000262367, ENST00000262367

ZINC - Substances

CBP_HUMAN

ZINC target

Q92793

PRO

Q92793

GlyGen

Q92793

PDB

1WO7, 5OWK, 8FXO, 6ALC, 5TB6, 5I83, 5KTU, 4TQN, 8HAM, 6FRF, 5LPJ, 7XIJ, 7UGL, 4N3W, 5EIC, 6ES5, 5I8G, 5W0F, 6FQT, 6YIJ, 6DMK, 7JFL, 1ZOQ, 5MPK, 8G6T, 5DBM, 5KTW, 2LXS, 2L85, 6ES6, 1LIQ, 2N1A, 7XHE, 6AXQ, 8FXN, 7XH6, 1RDT, 5I89, 4NR6, 7XNG, 3P1F, 4WHU, 5CGP, 1JSP, 4A9K, 7XI0, 5MMG, 5XXH, 8FXA, 5NLK, 8FXE, 6YIK, 7TB3, 6ALB, 8FUP, 8HAL, 4YK0, 2RNY, 6SQE, 3SVH, 2LXT, 7JUO, 5W0L, 1WO5, 1WO3, 5MPN, 5NRW, 8HAN, 3DWY, 7CO1, 5J0D, 6AY3, 6SQF, 5KTX, 4NR5, 5SVH, 4OUF, 3P1E, 8GA2, 6SXX, 7XM7, 6YIL, 5MPZ, 6ES7, 5NU3, 5LPL, 6FR0, 3P1C, 7JFM, 2KWF, 6QST, 8FV2, 4NYX, 6M64, 5MQG, 2L84, 5GH9, 7UGE, 1WO6, 1WO4, 6AY5, 4NR7, 5EP7, 7RLE, 4N4F, 4NR4, 7TBH, 5I8B, 4NYV, 3P1D, 5ENG, 7XNE, 5H85, 5JEM, 5W0Q, 6YIM, 5MME, 2KJE, 7KPY, 5MQE, 6FQO, 6FQU, 4TS8, 6LQX, 4NYW, 5I86, 6SQM, 2D82, 7WX2, 5MQK, 5W0E, 7EVJ

HPA

ENSG00000005339-CREBBP

Pharos - Targets

Q92793

Orphanet

CREBBP

ZINC - Predictions - Purchasable

CBP_HUMAN

HMDB Protein

HMDBP00014

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.96	17
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.929	12
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.757	6
UniProt:P03259 E1A			0.743	5
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.725	5
UniProt:Q6ZUJ4 CC062			0.671	6
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.669	4
UniProt:P03255 E1A			0.656	3
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.656	4
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.628	3
UniProt:Q13568 IRF5	3	IRF5 [cytosol] (R-HSA-1015676) p-S446-IRF5 [cytosol] (R-HSA-9860271) p-S446-IRF5 [nucleoplasm] (R-HSA-9860304)	0.618	3
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.618	6
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.609	2
UniProt:P03259-2			0.602	3
UniProt:P55209 NP1L1			0.593	3
UniProt:P16220 CREB1			0.589	2
UniProt:P48551 IFNAR2			0.576	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.573	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.573	2
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.571	2
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.564	3
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.564	3
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.564	2
IntAct:EBI-15697717 P53K382AC			0.558	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.536	2
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.528	3
UniProt:Q9Y6Q9 NCOA3	2	p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005) NCOA3 [nucleoplasm] (R-HSA-442488)	0.527	12
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.527	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.527	2
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.527	2
UniProt:Q9Y463 DYR1B			0.527	2
IntAct:EBI-1566585 IL8			0.527	2
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	3
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.527	2
ChEBI:83406 MS-417			0.525	2
UniProt:Q9UL17 TBX21			0.524	4
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.504	9
UniProt:P03070 LT			0.499	3
UniProt:P36956-1 SREBF1	5	SREBF1-1 [endoplasmic reticulum membrane] (R-HSA-1655757) SREBF1-1 [Golgi membrane] (R-HSA-1655753) SREBF1-1(1-530) [Golgi membrane] (R-HSA-1655718) SREBF1-1(1-490) [cytosol] (R-HSA-1655764) SREBF1-1(1-490) [nucleoplasm] (R-HSA-1655755)	0.499	3
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.499	2
UniProt:P36956-3 SREBF1	5	SREBF1-3 [nucleoplasm] (R-HSA-1655716) SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761) SREBF1-3 [Golgi membrane] (R-HSA-1655760) SREBF1-3 [Golgi membrane] (R-HSA-1655724) SREBF1-3 [cytosol] (R-HSA-1655721)	0.499	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.499	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.499	2
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.499	2
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.483	2
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.483	2

Cite Us!