p75NTR interacts with the NOGO receptor

Stable Identifier
R-HSA-193636
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The p75NTR extracellular domain interacts with NOGO receptor (NgR), a glycosyl phosphatidylinositol (GPI)-anchored protein present as a homomultimer at the cell surface. As NgR lacks an intracellular domain, it utilizes p75NTR as a co-receptor for intracellular signalling.

Literature References
PubMed ID Title Journal Year
11201742 Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

Fournier, AE, GrandPre, T, Strittmatter, SM

Nature 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed