NRAGE signals death through JNK

Stable Identifier
R-HSA-193648
Type
Pathway
Species
Homo sapiens
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Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

Literature References
PubMed ID Title Journal Year
12376548 NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway

Salehi, AH, Xanthoudakis, S, Barker, PA

J Biol Chem 2002
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Orthologous Events
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