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NRAGE signals death through JNK
Stable Identifier
R-HSA-193648
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
General
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Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.
Literature References
PubMed ID
Title
Journal
Year
12376548
NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway
Xanthoudakis, S
,
Salehi, AH
,
Barker, PA
J Biol Chem
2002
Participants
Events
NGF:p75NTR complex binds to NRAGE
(Homo sapiens)
NRAGE sequesters CHE1 in the cytoplasm
(Homo sapiens)
NRAGE activates JNK
(Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
(Homo sapiens)
GTP-bound RAC contributes to JNK activation
(Homo sapiens)
JNK phosphorylates BIM, BAD and other targets
(Homo sapiens)
Active JNK moves to the nucleus and phosphorylates different transcription factors
(Homo sapiens)
Participates
as an event of
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
Event Information
Go Biological Process
positive regulation of apoptotic process (0043065)
Orthologous Events
NRAGE signals death through JNK (Bos taurus)
NRAGE signals death through JNK (Caenorhabditis elegans)
NRAGE signals death through JNK (Canis familiaris)
NRAGE signals death through JNK (Danio rerio)
NRAGE signals death through JNK (Dictyostelium discoideum)
NRAGE signals death through JNK (Drosophila melanogaster)
NRAGE signals death through JNK (Gallus gallus)
NRAGE signals death through JNK (Mus musculus)
NRAGE signals death through JNK (Rattus norvegicus)
NRAGE signals death through JNK (Saccharomyces cerevisiae)
NRAGE signals death through JNK (Schizosaccharomyces pombe)
NRAGE signals death through JNK (Sus scrofa)
NRAGE signals death through JNK (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000466
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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