NRAGE signals death through JNK

Stable Identifier
R-HSA-193648
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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NRAGE signals death through JNK
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Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

Literature References
PubMed ID Title Journal Year
12376548 NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway

Xanthoudakis, S, Salehi, AH, Barker, PA

J Biol Chem 2002
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Events
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Event Information
Go Biological Process
positive regulation of apoptotic process (0043065)
Orthologous Events
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NRAGE signals death through JNK (Drosophila melanogaster)
NRAGE signals death through JNK (Gallus gallus)
NRAGE signals death through JNK (Mus musculus)
NRAGE signals death through JNK (Plasmodium falciparum)
NRAGE signals death through JNK (Rattus norvegicus)
NRAGE signals death through JNK (Saccharomyces cerevisiae)
NRAGE signals death through JNK (Sus scrofa)
NRAGE signals death through JNK (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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