p75NTR and RHOA-GDI interact

Stable Identifier
R-HSA-193668
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
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p75NTR directly complexes with RHO-GDI (RHO-GDP Dissociation Inhibitor). RHO-GDI inhibits the dissociation of GDP and the subsequent binding of GTP to RHOA, thus preventing formation of active RHOA. Once bound to p75NTR, RHOA-GDI is less active. p75NTR acts on RHOB in a similar mechanism.

Literature References
PubMed ID Title Journal Year
12692556 The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

Yamashita, T, Tohyama, M

Nat Neurosci 2003
9195882 A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

Keep, NH, Barnes, M, Barsukov, I, Badii, R, Lian, LY, Segal, AW, Moody, PC, Roberts, GC

Structure 1997
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created