Ceramide signalling

Stable Identifier
R-HSA-193681
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Pathway
Species
Homo sapiens
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In certain cell types, ligand binding to p75NTR leads to ceramide production, which can mediate either cell survival (e.g. in noecotical subplate neurons) or apoptosis (e.g. in oligodendrocytes). Low levels of ceramide are also able to stimulate axonal outgrowth in hippocampal neurons.

Literature References
PubMed ID Title Journal Year
12676795 Trk receptors: roles in neuronal signal transduction

Huang, EJ, Reichardt, LF

Annu Rev Biochem 2003
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