IRAK interacts with TRAF6

Stable Identifier
R-HSA-193695
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Neurotrophin binding to p75NTR leads to recruitment of TRAF6. This protein is an E3 ubiquitin ligase, which, together with an E2 Ubiquitin conjugating enzyme, mediates the assembly of lysine 63-linked polyubiquitin chains and their attachment to a lysine of a substrate protein. Activation of IRAK1 promotes recruitment of TRAF6. TRAF6 is able to bind to p75NTR (juxtamembrane region, residues 113-128), IRAK1 (N-terminal residues 1-198 and C-terminal residues 523-618), and MYD88. It might be recruited through the MYD88:IRAK1 complex.

Literature References
PubMed ID Title Journal Year
9915784 Association of the p75 neurotrophin receptor with TRAF6

Khursigara, G, Orlinick, JR, Chao, MV

J Biol Chem 1999
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Orthologous Events
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