p75NTR ICD signals to NF-kB

Stable Identifier
R-HSA-193700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The p75NTR ICD has the potential to bind many intracellular proteins, including TRAF6, SC1, NADE, NRAGE, and RHOA. It may bring these proteins to function in different cellular compartments. p75NTR ICD was shown to activate NF-kB via TRAF6.

Literature References
PubMed ID Title Journal Year
12843241 Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability

Kanning, KC, Hudson, M, Amieux, PS, Wiley, JC, Bothwell, M, Schecterson, LC

J Neurosci 2003
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