IKKbeta is activated

Stable Identifier
R-HSA-193703
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Atypical PKC isoforms phosphorylate the beta subunit of the IKK complex (on Serines 177 and 181) thereby serving as an IKK kinase. TRAF6 and p62 as well appear to have a role in IKK activation. TRAF6 mediates the assembly of K63-linked poly-Ub chains required for IKK activation. The ubiquitin binding property of p62 may also be relevant in regulating IKK activation.

Literature References
PubMed ID Title Journal Year
10022904 Activation of IkappaB kinase beta by protein kinase C isoforms

Lallena, MJ, Diaz-Meco, MT, Bren, G, Paya, CV, Moscat, J

Mol Cell Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created