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MYD88 dimer [cytosol]
Stable Identifier
R-HSA-193932
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
2xMYD88, MYD88 homodimer
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
IRAK is activated (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
MYD88 dissociates (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
Participants
components
x 2
MYD88 [cytosol]
(Homo sapiens)
Participates
as an output of
MYD88 dissociates (Homo sapiens)
as a component of
IRAK1:MYD88 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
as an input of
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
Inferred To
MYD88 dimer [cytosol]
(Bos taurus)
MYD88 dimer [cytosol]
(Canis familiaris)
MYD88 dimer [cytosol]
(Danio rerio)
MYD88 dimer [cytosol]
(Gallus gallus)
MYD88 dimer [cytosol]
(Mus musculus)
MYD88 dimer [cytosol]
(Rattus norvegicus)
MYD88 dimer [cytosol]
(Sus scrofa)
MYD88 dimer [cytosol]
(Xenopus tropicalis)
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