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SQSTM1 [cytosol]
Stable Identifier
R-HSA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p62, Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O95817 BAG3
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Pexophagy (Homo sapiens)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13501 SQSTM1
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:1, initiator methionine:, chain:2-440
Reference Genes
BioGPS Gene:8878 SQSTM1
COSMIC (genes):SQSTM1 SQSTM1
CTD Gene:8878 SQSTM1
dbSNP Gene:8878 SQSTM1
ENSEMBL:ENSG00000161011 SQSTM1
HGNC:11280 SQSTM1
KEGG Gene (Homo sapiens):8878 SQSTM1
Monarch:8878 SQSTM1
NCBI Gene:8878 SQSTM1
OMIM:601530 SQSTM1
UCSC:Q13501 SQSTM1
Reference Transcript
RefSeq:NM_003900.4 SQSTM1
RefSeq:NM_001142298.1 SQSTM1
RefSeq:NM_001142299.1 SQSTM1
RefSeq:XM_017010010.1 SQSTM1
Other Identifiers
0000730647
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
201471_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
40898_at
8110569
8878
A_14_P109999
A_23_P81399
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000932
GO:0001934
GO:0002376
GO:0002931
GO:0003674
GO:0004674
GO:0005080
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006464
GO:0006468
GO:0006511
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0007005
GO:0007032
GO:0007165
GO:0007267
GO:0008104
GO:0008150
GO:0008219
GO:0008270
GO:0009056
GO:0009058
GO:0010821
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016301
GO:0016605
GO:0019899
GO:0019901
GO:0030017
GO:0030154
GO:0030971
GO:0031397
GO:0031410
GO:0031625
GO:0032182
GO:0034641
GO:0035255
GO:0035556
GO:0035973
GO:0042169
GO:0042802
GO:0043065
GO:0043066
GO:0043122
GO:0043130
GO:0043167
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0044877
GO:0045944
GO:0046578
GO:0046872
GO:0061635
GO:0061912
GO:0070062
GO:0070498
GO:0070530
GO:0097225
GO:0097413
GO:0098780
GO:1900273
GO:1903078
GO:1905719
Hs.279891.1.A1_3p_at
ILMN_1662618
ILMN_1703856
PH_hs_0010763
U46751_at
g4505570_3p_s_at
Participant Of
hasComponent
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane]
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane]
MAP3K3:SQSTM1 [cytosol]
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane]
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane]
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane]
Ubiquitinated NRIF:Sequestosome [cytosol]
input
p62 binds ubiquitinated mitochondrial substrates
p62 is recruited and forms a complex with TRAF6
Polyubiquitinated NRIF binds to p62 (Sequestosome)
SQSTM1 binds ATM dimer:Ub-p-PEX5
Other forms of this molecule
SQSTM1 [nucleoplasm]
Inferred To
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Dictyostelium discoideum)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Sus scrofa)
Sqstm1 [cytosol] (Mus musculus)
Sqstm1 [cytosol] (Rattus norvegicus)
ref(2)P [cytosol] (Drosophila melanogaster)
sqstm1 [cytosol] (Danio rerio)
sqstm1 [cytosol] (Xenopus tropicalis)
Ghost homologue of SQSTM1 [cytosol] (Schizosaccharomyces pombe)
sqst-2 [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
NP_003891.1
,
NP_001135770.1
,
NP_001135771.1
,
XP_016865499.1
OpenTargets
ENSG00000161011
GeneCards
Q13501
HPA
ENSG00000161011-SQSTM1
Ensembl
ENST00000360718
,
ENSP00000353944
,
ENST00000389805
,
ENSP00000374455
,
ENSG00000161011
PRO
Q13501
Orphanet
20429
PDB
6MJ7
,
5YP8
,
5YPH
,
5YPG
,
5YPC
,
5YPB
,
6KHZ
,
6TH3
,
4MJS
,
4UF9
,
6TGY
,
1Q02
,
5YPF
,
2K0B
,
5YP7
,
6JM4
,
4UF8
,
5YPE
,
5YPA
,
2JY8
,
2JY7
,
2KNV
Interactors (50)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
0.97
24
UniProt:P60520 GABARAPL2
3
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.961
20
UniProt:Q14145 KEAP1
2
KEAP1 [cytosol]
(R-HSA-976038)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.96
18
UniProt:O95166 GABARAP
3
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
GABARAP [autophagosome membrane]
(R-HSA-5683634)
0.893
14
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
0.893
15
UniProt:Q13501 SQSTM1
2
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
0.891
10
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
0.867
10
UniProt:P41743 PRKCI
3
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [plasma membrane]
(R-HSA-420005)
0.866
10
IntAct:EBI-4399559 UBIQ
0.829
6
UniProt:P0CG48 UBC
325
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
Ub-443-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783153)
Ub-139-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783155)
Ub-63-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783094)
Ub-671-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783083)
Ub-519-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783053)
Ub-367-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783105)
Ub-215-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783137)
Ub-386-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783067)
Ub-6-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783122)
Ub-310-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783027)
Ub-234-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783157)
Ub-614-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783063)
Ub-462-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783118)
Ub-538-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783011)
Ub-158-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783140)
Ub-82-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783175)
Ub-315-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783089)
Ub-163-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783091)
Ub-543-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783060)
Ub-239-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783092)
Ub-619-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783125)
Ub-467-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783181)
Ub-11-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783104)
Ub-391-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783170)
Ub-87-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783110)
Ub-656-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783134)
Ub-124-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783120)
Ub-428-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783090)
Ub-48-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783029)
Ub-504-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783113)
Ub-200-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783150)
Ub-580-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783119)
Ub-276-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783183)
Ub-352-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783201)
Ub-29-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783064)
Ub-182-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783097)
Ub-486-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783194)
Ub-334-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783199)
Ub-638-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783188)
Ub-106-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783031)
Ub-258-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783016)
Ub-562-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783172)
Ub-410-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783077)
Ub-636-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783128)
Ub-104-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783032)
Ub-256-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783004)
Ub-484-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783156)
Ub-27-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783022)
Ub-332-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783138)
Ub-180-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783107)
Ub-408-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783108)
Ub-560-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783174)
N6-glycyl-L-lysine-UBC(457-532) [cytosol]
(R-HSA-8869048)
N6-glycyl-L-lysine-UBC(609-684) [cytosol]
(R-HSA-8869052)
N6-glycyl-L-lysine-UBC(229-304) [cytosol]
(R-HSA-8869032)
N6-glycyl-L-lysine-UBC(533-608) [cytosol]
(R-HSA-8869033)
N6-glycyl-L-lysine-UBC(153-228) [cytosol]
(R-HSA-8869035)
N6-glycyl-L-lysine-UBC(305-380) [cytosol]
(R-HSA-8869036)
N6-glycyl-L-lysine-UBC(77-152) [cytosol]
(R-HSA-8869026)
N6-glycyl-L-lysine-UBC(1-76) [cytosol]
(R-HSA-8869030)
N6-glycyl-L-lysine-UBC(381-456) [cytosol]
(R-HSA-8869031)
adenylatedG608-UBC(533-608) [nucleoplasm]
(R-HSA-8852090)
adenylatedG380-UBC(305-380) [nucleoplasm]
(R-HSA-8852093)
adenylatedG532-UBC(457-532) [nucleoplasm]
(R-HSA-8852081)
adenylatedG304-UBC(229-304) [nucleoplasm]
(R-HSA-8852050)
adenylatedG152-UBC(77-152) [nucleoplasm]
(R-HSA-8852054)
adenylatedG684-UBC(609-684) [nucleoplasm]
(R-HSA-8852105)
adenylatedG228-UBC(153-228) [nucleoplasm]
(R-HSA-8852075)
adenylatedG76-UBC(1-76) [nucleoplasm]
(R-HSA-8852044)
adenylatedG456-UBC(381-456) [nucleoplasm]
(R-HSA-8852098)
UBC [cytosol]
(R-HSA-8853531)
adenylatedG380-UBC(305-380) [cytosol]
(R-HSA-8852062)
adenylatedG608-UBC(533-608) [cytosol]
(R-HSA-8852052)
adenylatedG76-UBC(1-76) [cytosol]
(R-HSA-8852053)
adenylatedG304-UBC(229-304) [cytosol]
(R-HSA-8852117)
adenylatedG684-UBC(609-684) [cytosol]
(R-HSA-8852118)
adenylatedG152-UBC(77-152) [cytosol]
(R-HSA-8852087)
adenylatedG532-UBC(457-532) [cytosol]
(R-HSA-8852045)
adenylatedG228-UBC(153-228) [cytosol]
(R-HSA-8852111)
adenylatedG456-UBC(381-456) [cytosol]
(R-HSA-8852069)
Ub-428-UBC(381-456) [endoplasmic reticulum membrane]
(R-HSA-8943062)
Ub-656-UBC(609-684) [endoplasmic reticulum membrane]
(R-HSA-8943120)
Ub-124-UBC(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943129)
Ub-48-UBC(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943079)
Ub-352-UBC(305-380) [endoplasmic reticulum membrane]
(R-HSA-8943108)
Ub-504-UBC(457-532) [endoplasmic reticulum membrane]
(R-HSA-8943075)
Ub-276-UBC(229-304) [endoplasmic reticulum membrane]
(R-HSA-8943106)
Ub-580-UBC(533-608) [endoplasmic reticulum membrane]
(R-HSA-8943137)
Ub-200-UBC(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943087)
UBC(1-76) [plasma membrane]
(R-HSA-3149469)
UBC(457-532) [plasma membrane]
(R-HSA-3149468)
UBC(153-228) [plasma membrane]
(R-HSA-3149467)
UBC(609-684) [plasma membrane]
(R-HSA-3149466)
UBC(77-152) [plasma membrane]
(R-HSA-3149465)
UBC(229-304) [plasma membrane]
(R-HSA-3149464)
UBC(533-608) [plasma membrane]
(R-HSA-3149462)
UBC(381-456) [plasma membrane]
(R-HSA-3149459)
UBC(305-380) [plasma membrane]
(R-HSA-3149458)
UBC(1-76) [endosome membrane]
(R-HSA-939187)
UBC(533-608) [endosome membrane]
(R-HSA-939221)
UBC(77-152) [endosome membrane]
(R-HSA-939161)
UBC(305-380) [endosome membrane]
(R-HSA-939196)
UBC(457-532) [endosome membrane]
(R-HSA-939199)
UBC(381-456) [endosome membrane]
(R-HSA-939166)
UBC(153-228) [endosome membrane]
(R-HSA-939170)
UBC(609-684) [endosome membrane]
(R-HSA-939237)
UBC(229-304) [endosome membrane]
(R-HSA-939172)
UBC(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943095)
UBC(381-456) [endoplasmic reticulum membrane]
(R-HSA-8943126)
UBC(533-608) [endoplasmic reticulum membrane]
(R-HSA-8943061)
UBC(609-684) [endoplasmic reticulum membrane]
(R-HSA-8943135)
UBC(229-304) [endoplasmic reticulum membrane]
(R-HSA-8943103)
UBC(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943068)
UBC(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943077)
UBC(305-380) [endoplasmic reticulum membrane]
(R-HSA-8943084)
UBC(457-532) [endoplasmic reticulum membrane]
(R-HSA-8943112)
Ub-29-UBC(1-76) [cytosol]
(R-HSA-5689165)
Ub-258-UBC(229-304) [cytosol]
(R-HSA-5689167)
Ub-334-UBC(305-380) [cytosol]
(R-HSA-5689166)
Ub-410-UBC(381-456) [cytosol]
(R-HSA-5689185)
Ub-486-UBC(457-532) [cytosol]
(R-HSA-5689176)
Ub-562-UBC(533-608) [cytosol]
(R-HSA-5689151)
Ub-106-UBC(77-152) [cytosol]
(R-HSA-5689183)
Ub-182-UBC(153-228) [cytosol]
(R-HSA-5689169)
Ub-638-UBC(609-684) [cytosol]
(R-HSA-5689136)
Ub-310-UBC(305-380) [cytosol]
(R-HSA-5689097)
Ub-6-UBC(1-76) [cytosol]
(R-HSA-5689091)
Ub-462-UBC(457-532) [cytosol]
(R-HSA-5689092)
Ub-386-UBC(381-456) [cytosol]
(R-HSA-5689086)
Ub-538-UBC(533-608) [cytosol]
(R-HSA-5689104)
Ub-158-UBC(153-228) [cytosol]
(R-HSA-5689107)
Ub-614-UBC(609-684) [cytosol]
(R-HSA-5689076)
Ub-234-UBC(229-304) [cytosol]
(R-HSA-5689110)
Ub-82-UBC(77-152) [cytosol]
(R-HSA-5689078)
Ub-110-UBC(77-152) [cytosol]
(R-HSA-5689196)
Ub-33-UBC(1-76) [cytosol]
(R-HSA-5689134)
Ub-488-UBC(457-532) [cytosol]
(R-HSA-5689153)
Ub-338-UBC(305-380) [cytosol]
(R-HSA-5689152)
Ub-642-UBC(609-684) [cytosol]
(R-HSA-5689218)
Ub-414-UBC(381-456) [cytosol]
(R-HSA-5689157)
Ub-262-UBC(229-304) [cytosol]
(R-HSA-5689150)
Ub-566-UBC(533-608) [cytosol]
(R-HSA-5689205)
Ub-186-UBC(153-228) [cytosol]
(R-HSA-5689140)
Ub-256-UBC(229-304) [cytosol]
(R-HSA-5689135)
Ub-180-UBC(153-228) [cytosol]
(R-HSA-5689221)
Ub-104-UBC(77-152) [cytosol]
(R-HSA-5689189)
Ub-484-UBC(457-532) [cytosol]
(R-HSA-5689220)
Ub-560-UBC(533-608) [cytosol]
(R-HSA-5689145)
Ub-636-UBC(609-684) [cytosol]
(R-HSA-5689144)
Ub-332-UBC(305-380) [cytosol]
(R-HSA-5689211)
Ub-27-UBC(1-76) [cytosol]
(R-HSA-5689179)
Ub-408-UBC(381-456) [cytosol]
(R-HSA-5689182)
Ub-87-UBC(77-152) [cytosol]
(R-HSA-3095920)
Ub-163-UBC(153-228) [cytosol]
(R-HSA-3095924)
Ub-619-UBC(609-684) [cytosol]
(R-HSA-3095925)
Ub-467-UBC(457-532) [cytosol]
(R-HSA-3095935)
Ub-11-UBC(1-76) [cytosol]
(R-HSA-3095906)
Ub-543-UBC(533-608) [cytosol]
(R-HSA-3095912)
Ub-391-UBC(381-456) [cytosol]
(R-HSA-3095914)
Ub-315-UBC(305-380) [cytosol]
(R-HSA-3095916)
Ub-239-UBC(229-304) [cytosol]
(R-HSA-3095919)
Ub-519-UBC(457-532) [endosome membrane]
(R-HSA-939227)
Ub-367-UBC(305-380) [endosome membrane]
(R-HSA-939162)
Ub-291-UBC(229-304) [endosome membrane]
(R-HSA-939226)
Ub-443-UBC(381-456) [endosome membrane]
(R-HSA-939204)
Ub-215-UBC(153-228) [endosome membrane]
(R-HSA-939175)
Ub-63-UBC(1-76) [endosome membrane]
(R-HSA-939174)
Ub-595-UBC(533-608) [endosome membrane]
(R-HSA-939242)
Ub-139-UBC(77-152) [endosome membrane]
(R-HSA-939244)
Ub-671-UBC(609-684) [endosome membrane]
(R-HSA-939183)
Ub-291-UBC(229-304) [plasma membrane]
(R-HSA-939859)
Ub-595-UBC(533-608) [plasma membrane]
(R-HSA-939858)
Ub-367-UBC(305-380) [plasma membrane]
(R-HSA-939861)
Ub-63-UBC(1-76) [plasma membrane]
(R-HSA-939860)
Ub-139-UBC(77-152) [plasma membrane]
(R-HSA-939865)
Ub-215-UBC(153-228) [plasma membrane]
(R-HSA-939864)
Ub-519-UBC(457-532) [plasma membrane]
(R-HSA-939845)
Ub-671-UBC(609-684) [plasma membrane]
(R-HSA-939846)
Ub-443-UBC(381-456) [plasma membrane]
(R-HSA-939848)
Ub-408-UBC(381-456) [nucleoplasm]
(R-HSA-6782681)
Ub-484-UBC(457-532) [nucleoplasm]
(R-HSA-6782650)
Ub-104-UBC(77-152) [nucleoplasm]
(R-HSA-6782651)
Ub-256-UBC(229-304) [nucleoplasm]
(R-HSA-6782641)
Ub-180-UBC(153-228) [nucleoplasm]
(R-HSA-6782603)
Ub-560-UBC(533-608) [nucleoplasm]
(R-HSA-6782637)
Ub-27-UBC(1-76) [nucleoplasm]
(R-HSA-6782625)
Ub-636-UBC(609-684) [nucleoplasm]
(R-HSA-6782597)
Ub-332-UBC(305-380) [nucleoplasm]
(R-HSA-6782630)
Ub-638-UBC(609-684) [nucleoplasm]
(R-HSA-6782680)
Ub-258-UBC(229-304) [nucleoplasm]
(R-HSA-6782621)
Ub-562-UBC(533-608) [nucleoplasm]
(R-HSA-6782672)
Ub-410-UBC(381-456) [nucleoplasm]
(R-HSA-6782642)
Ub-182-UBC(153-228) [nucleoplasm]
(R-HSA-6782678)
Ub-106-UBC(77-152) [nucleoplasm]
(R-HSA-6782602)
Ub-334-UBC(305-380) [nucleoplasm]
(R-HSA-6782638)
Ub-29-UBC(1-76) [nucleoplasm]
(R-HSA-6782659)
Ub-486-UBC(457-532) [nucleoplasm]
(R-HSA-6782661)
Ub-48-UBC(1-76) [nucleoplasm]
(R-HSA-6782524)
Ub-428-UBC(381-456) [nucleoplasm]
(R-HSA-6782462)
Ub-504-UBC(457-532) [nucleoplasm]
(R-HSA-6782512)
Ub-276-UBC(229-304) [nucleoplasm]
(R-HSA-6782482)
Ub-200-UBC(153-228) [nucleoplasm]
(R-HSA-6782487)
Ub-656-UBC(609-684) [nucleoplasm]
(R-HSA-6782474)
Ub-580-UBC(533-608) [nucleoplasm]
(R-HSA-6782477)
Ub-124-UBC(77-152) [nucleoplasm]
(R-HSA-6782498)
Ub-352-UBC(305-380) [nucleoplasm]
(R-HSA-6782467)
Ub-467-UBC(457-532) [nucleoplasm]
(R-HSA-6782619)
Ub-163-UBC(153-228) [nucleoplasm]
(R-HSA-6782622)
Ub-11-UBC(1-76) [nucleoplasm]
(R-HSA-6782609)
Ub-87-UBC(77-152) [nucleoplasm]
(R-HSA-6782632)
Ub-239-UBC(229-304) [nucleoplasm]
(R-HSA-6782669)
Ub-543-UBC(533-608) [nucleoplasm]
(R-HSA-6782594)
Ub-391-UBC(381-456) [nucleoplasm]
(R-HSA-6782626)
Ub-315-UBC(305-380) [nucleoplasm]
(R-HSA-6782660)
Ub-619-UBC(609-684) [nucleoplasm]
(R-HSA-6782662)
Ub-186-UBC(153-228) [nucleoplasm]
(R-HSA-6782617)
Ub-338-UBC(305-380) [nucleoplasm]
(R-HSA-6782620)
Ub-33-UBC(1-76) [nucleoplasm]
(R-HSA-6782653)
Ub-110-UBC(77-152) [nucleoplasm]
(R-HSA-6782590)
Ub-262-UBC(229-304) [nucleoplasm]
(R-HSA-6782640)
Ub-642-UBC(609-684) [nucleoplasm]
(R-HSA-6782674)
Ub-566-UBC(533-608) [nucleoplasm]
(R-HSA-6782646)
Ub-414-UBC(381-456) [nucleoplasm]
(R-HSA-6782636)
Ub-488-UBC(457-532) [nucleoplasm]
(R-HSA-6782599)
UBC(229-304) [nucleoplasm]
(R-HSA-939857)
UBC(381-456) [nucleoplasm]
(R-HSA-939856)
UBC(305-380) [nucleoplasm]
(R-HSA-939863)
UBC(457-532) [nucleoplasm]
(R-HSA-939862)
UBC(533-608) [nucleoplasm]
(R-HSA-939866)
UBC(77-152) [nucleoplasm]
(R-HSA-939869)
UBC(609-684) [nucleoplasm]
(R-HSA-939868)
UBC(1-76) [nucleoplasm]
(R-HSA-939871)
UBC(153-228) [nucleoplasm]
(R-HSA-939853)
Ub-124-UBC(77-152) [nucleoplasm]
(R-HSA-5683048)
Ub-580-UBC(533-608) [nucleoplasm]
(R-HSA-5683050)
Ub-428-UBC(381-456) [nucleoplasm]
(R-HSA-5683041)
Ub-276-UBC(229-304) [nucleoplasm]
(R-HSA-5683042)
Ub-352-UBC(305-380) [nucleoplasm]
(R-HSA-5683045)
Ub-200-UBC(153-228) [nucleoplasm]
(R-HSA-5683046)
Ub-48-UBC(1-76) [nucleoplasm]
(R-HSA-5683033)
Ub-656-UBC(609-684) [nucleoplasm]
(R-HSA-5683035)
Ub-504-UBC(457-532) [nucleoplasm]
(R-HSA-5683039)
Ub-671-UBC(609-684) [nucleoplasm]
(R-HSA-6782523)
Ub-215-UBC(153-228) [nucleoplasm]
(R-HSA-6782491)
Ub-63-UBC(1-76) [nucleoplasm]
(R-HSA-6782492)
Ub-443-UBC(381-456) [nucleoplasm]
(R-HSA-6782480)
Ub-367-UBC(305-380) [nucleoplasm]
(R-HSA-6782479)
Ub-139-UBC(77-152) [nucleoplasm]
(R-HSA-6782496)
Ub-519-UBC(457-532) [nucleoplasm]
(R-HSA-6782497)
Ub-595-UBC(533-608) [nucleoplasm]
(R-HSA-6782499)
Ub-291-UBC(229-304) [nucleoplasm]
(R-HSA-6782500)
Ub-82-UBC(77-152) [nucleoplasm]
(R-HSA-6782675)
Ub-6-UBC(1-76) [nucleoplasm]
(R-HSA-6782611)
Ub-234-UBC(229-304) [nucleoplasm]
(R-HSA-6782677)
Ub-158-UBC(153-228) [nucleoplasm]
(R-HSA-6782645)
Ub-310-UBC(305-380) [nucleoplasm]
(R-HSA-6782614)
Ub-538-UBC(533-608) [nucleoplasm]
(R-HSA-6782664)
Ub-462-UBC(457-532) [nucleoplasm]
(R-HSA-6782634)
Ub-386-UBC(381-456) [nucleoplasm]
(R-HSA-6782605)
Ub-614-UBC(609-684) [nucleoplasm]
(R-HSA-6782657)
UBC(609-684) [late endosome lumen]
(R-HSA-9660012)
UBC(153-228) [late endosome lumen]
(R-HSA-9659979)
UBC(305-380) [late endosome lumen]
(R-HSA-9660033)
UBC(77-152) [late endosome lumen]
(R-HSA-9659992)
UBC(533-608) [late endosome lumen]
(R-HSA-9659993)
UBC(229-304) [late endosome lumen]
(R-HSA-9659994)
UBC(457-532) [late endosome lumen]
(R-HSA-9659995)
UBC(381-456) [late endosome lumen]
(R-HSA-9660023)
UBC(1-76) [late endosome lumen]
(R-HSA-9659985)
Ub-48-UBC(1-76) [cytosol]
(R-HSA-939219)
Ub-656-UBC(609-684) [cytosol]
(R-HSA-939255)
Ub-428-UBC(381-456) [cytosol]
(R-HSA-939190)
Ub-504-UBC(457-532) [cytosol]
(R-HSA-939257)
Ub-580-UBC(533-608) [cytosol]
(R-HSA-939256)
Ub-276-UBC(229-304) [cytosol]
(R-HSA-939207)
Ub-124-UBC(77-152) [cytosol]
(R-HSA-939209)
Ub-200-UBC(153-228) [cytosol]
(R-HSA-939179)
Ub-352-UBC(305-380) [cytosol]
(R-HSA-939181)
UBC(457-532) [cytosol]
(R-HSA-939184)
UBC(1-76) [cytosol]
(R-HSA-939188)
UBC(381-456) [cytosol]
(R-HSA-939191)
UBC(229-304) [cytosol]
(R-HSA-939192)
UBC(153-228) [cytosol]
(R-HSA-939258)
UBC(609-684) [cytosol]
(R-HSA-939165)
UBC(77-152) [cytosol]
(R-HSA-939164)
UBC(305-380) [cytosol]
(R-HSA-939232)
UBC(533-608) [cytosol]
(R-HSA-939239)
UBC(1-76) [lysosomal lumen]
(R-HSA-9659981)
UBC(305-380) [lysosomal lumen]
(R-HSA-9660008)
UBC(77-152) [lysosomal lumen]
(R-HSA-9659978)
UBC(609-684) [lysosomal lumen]
(R-HSA-9660020)
UBC(153-228) [lysosomal lumen]
(R-HSA-9659988)
UBC(457-532) [lysosomal lumen]
(R-HSA-9659989)
UBC(381-456) [lysosomal lumen]
(R-HSA-9659984)
UBC(229-304) [lysosomal lumen]
(R-HSA-9660018)
UBC(533-608) [lysosomal lumen]
(R-HSA-9659987)
Ub-215-UBC(153-228) [cytosol]
(R-HSA-939186)
Ub-139-UBC(77-152) [cytosol]
(R-HSA-939254)
Ub-595-UBC(533-608) [cytosol]
(R-HSA-939198)
Ub-291-UBC(229-304) [cytosol]
(R-HSA-939173)
Ub-367-UBC(305-380) [cytosol]
(R-HSA-939206)
Ub-671-UBC(609-684) [cytosol]
(R-HSA-939241)
Ub-63-UBC(1-76) [cytosol]
(R-HSA-939176)
Ub-519-UBC(457-532) [cytosol]
(R-HSA-939212)
Ub-443-UBC(381-456) [cytosol]
(R-HSA-939182)
0.806
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.806
8
UniProt:Q14596 NBR1
2
NBR1 [cytosol]
(R-HSA-9665180)
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
0.784
7
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.728
9
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.702
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.688
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.676
18
UniProt:Q15038 DAZP2
0.666
4
UniProt:P54253 ATX1
0.666
4
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.666
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.649
8
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.635
3
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
SUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.591
4
UniProt:Q6IRU7
1
Cep78 [cytosol]
(R-MMU-380304)
0.564
2
UniProt:Q15334 L2GL1
0.564
2
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.558
7
UniProt:Q9UGJ0 PRKAG2
3
PRKAG2 [nucleoplasm]
(R-HSA-164130)
PRKAG2 [cytosol]
(R-HSA-200416)
PRKAG2 [cytosol]
(R-HSA-200419)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:O14576-2 O145762
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:A0A024RC47 A0A024RC47
0.556
3
UniProt:P19544-6 WT1
0.556
3
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [cytosol]
(R-HSA-6792602)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
0.556
3
UniProt:P12709
4
PGI1 [extracellular region]
(R-SCE-6806478)
PGI1 [ficolin-1-rich granule lumen]
(R-SCE-6801506)
PGI1 [secretory granule lumen]
(R-SCE-6801495)
PGI1 [cytosol]
(R-SCE-70468)
0.556
3
UniProt:A8K2U6 A8K2U6
0.556
3
IntAct:EBI-25830852 RZPDO839G03145
0.556
3
UniProt:P07437 TUBB
3
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
TUBB [extracellular region]
(R-HSA-380317)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
6
UniProt:P84022 SMAD3
21
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.543
3
UniProt:Q2V2M9 FHOD3
0.543
6
UniProt:Q2V2M9-4 FHOD3
0.543
4
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.537
3
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.527
4
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.524
2
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [cytosol]
(R-HSA-182957)
SH3KBP1 [plasma membrane]
(R-HSA-182955)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.524
4
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.524
2
UniProt:P38182
12
ATG8 [cytosol]
(R-SCE-5205651)
ATG8 [cytosol]
(R-SCE-5205676)
ATG8 [cytosol]
(R-SCE-975521)
ATG8 [cytosol]
(R-SCE-5679223)
ATG8 [cytosol]
(R-SCE-5682696)
ATG8 [cytosol]
(R-SCE-5682674)
ATG8 [cytosol]
(R-SCE-5682653)
ATG8 [cytosol]
(R-SCE-5682681)
ATG8 [autophagosome membrane]
(R-SCE-5683634)
ATG8 [autophagosome membrane]
(R-SCE-5683638)
ATG8 [autophagosome membrane]
(R-SCE-5683640)
ATG8 [autophagosome membrane]
(R-SCE-5683641)
0.508
3
UniProt:O70405
7
phospho-Ulk1 [cytosol]
(R-MMU-5672131)
Ulk1 [recycling endosome]
(R-MMU-8854761)
phospho-Ulk1 [cytosol]
(R-MMU-5673747)
phospho-Ulk1 [cytosol]
(R-MMU-5675858)
phospho-Ulk1 [endoplasmic reticulum membrane]
(R-MMU-8948047)
Ulk1 [mitochondrial outer membrane]
(R-MMU-8948145)
Ulk1 [cytosol]
(R-MMU-1632847)
0.499
2
UniProt:P12504 VIF
0.499
2
UniProt:P04629 NTRK1
4
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
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