CYP21A2 oxidises 17HPROG

Stable Identifier
R-HSA-193981
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol, 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
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17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.

Literature References
PubMed ID Title Journal Year
3038528 Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia

Rodrigues, NR, Dunham, I, Yu, CY, Carroll, MC, Porter, RR, Campbell, RD

EMBO J 1987
3487786 Structure of human steroid 21-hydroxylase genes

White, PC, New, MI, Dupont, B

Proc Natl Acad Sci U S A 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid 21-monooxygenase activity of CYP21A2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created