CYP11B1 oxidises 11DCORT

Stable Identifier
R-HSA-193997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
11-deoxycortisol is oxidised to cortisol by CYP11B1, 11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
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Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydroxylates 11-deoxycortisol (11DCORT) to form cortisol (CORT). CYP11B1 is associated with the inner mitochondrial membrane. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor, melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
PubMed ID Title Journal Year
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
1741400 Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

Kawamoto, T, Mitsuuchi, Y, Toda, K, Yokoyama, Y, Miyahara, K, Miura, S, Ohnishi, T, Ichikawa, Y, Nakao, K, Imura, H, Ulick, S, Shizuta, Y

Proc Natl Acad Sci U S A 1992
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, Dupont, J, Vitek, A, White, PC

J Biol Chem 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]
Physical Entity
Activity
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Orthologous Events
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Created