HSD11B2,HSD11B1 dimer oxidise CORT to COR

Stable Identifier
R-HSA-194023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cortisol + NADP+ => cortisone + NADPH + H+
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Cortisol and NADP+ react to form cortisone, NADPH, and H+. This reaction is catalyzed by 11beta-hydroxysteroid dehydrogenases 11B1 and B2 (HSD11B1, B2), associated with the endoplasmic reticulum membrane. The conversion of cortisol (CORT), an active hormone, into inactive cortisone (COR) occurs in many tissues in the body, notably in the liver, and appears to play a role in regulating cortisol activity (Tannin et al. 1991, Stewart et al. 1987).

Literature References
PubMed ID Title Journal Year
1885595 The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

Tannin, GM, Agarwal, AK, Monder, C, New, MI, White, PC

J Biol Chem 1991
2889032 Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age

Stewart, PM, Wallace, AM, Valentino, R, Burt, D, Shackleton, CH, Edwards, CR

Lancet 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity of HSD11B2, HSD11B1 dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created