HSD11B2,HSD11B1 dimer oxidise CORT to COR

Stable Identifier
R-HSA-194023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cortisol + NADP+ => cortisone + NADPH + H+
ReviewStatus
5/5
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Cortisol and NADP+ react to form cortisone, NADPH, and H+. This reaction is catalyzed by 11beta-hydroxysteroid dehydrogenases 11B1 and B2 (HSD11B1, B2), associated with the endoplasmic reticulum membrane. The conversion of cortisol (CORT), an active hormone, into inactive cortisone (COR) occurs in many tissues in the body, notably in the liver, and appears to play a role in regulating cortisol activity (Tannin et al. 1991, Stewart et al. 1987).
Literature References
PubMed ID Title Journal Year
2889032 Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age

Wallace, AM, Stewart, PM, Edwards, CR, Valentino, R, Burt, D, Shackleton, CH

Lancet 1987
1885595 The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

New, MI, Tannin, GM, White, PC, Monder, C, Agarwal, AK

J Biol Chem 1991
Participants
Participates
Catalyst Activity

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity of HSD11B2, HSD11B1 dimer [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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