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NFKB1(1-433):RELA [cytosol]
Stable Identifier
R-HSA-194043
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
p50/p65 complex, NF-kB complex
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Ub-K21,22-p-S32,36-NFKBIA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
p75NTR ICD signals to NF-kB (Homo sapiens)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Participants
components
NFKB1(1-433) [cytosol]
(Homo sapiens)
RELA [cytosol]
(Homo sapiens)
Participates
as a component of
Ub-K21,22-p-S32,36-NFKBIA:NF-kB complex [cytosol] (Homo sapiens)
NF-kappaB p50:p65:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
as a member of
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
as an input of
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
p75NTR ICD signals to NF-kB (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
as an output of
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
Inferred To
NFKB1(1-433):RELA [cytosol]
(Bos taurus)
NFKB1(1-433):RELA [cytosol]
(Canis familiaris)
NFKB1(1-433):RELA [cytosol]
(Gallus gallus)
NFKB1(1-433):RELA [cytosol]
(Mus musculus)
NFKB1(1-433):RELA [cytosol]
(Sus scrofa)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
(Drosophila melanogaster)
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