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SLC10A1 [plasma membrane]
Stable Identifier
R-HSA-194116
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NTCP, Sodium/bile acid cotransporter, Na+ / taurocholate cotransporter
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)
SLC10A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14973 SLC10A1
Gene Names
SLC10A1, NTCP, GIG29
Chain
chain:1-349
Reference Genes
BioGPS Gene:6554 SLC10A1
COSMIC (genes):SLC10A1 SLC10A1
CTD Gene:6554 SLC10A1
dbSNP Gene:6554 SLC10A1
ENSEMBL:ENSG00000100652 SLC10A1
ENSEMBL_homo_sapiens_GENE:ENSG00000100652.5 SLC10A1
HGNC:10905 SLC10A1
KEGG Gene (Homo sapiens):6554 SLC10A1
Monarch:6554 SLC10A1
NCBI Gene:6554 SLC10A1
OMIM:182396 SLC10A1
UCSC:Q14973 SLC10A1
Reference Transcript
RefSeq:NM_003049.3 SLC10A1
Other Identifiers
11734115_at
16794268
207185_PM_at
207185_at
34035_at
3570267
3570268
3570269
3570270
3570271
3570272
3570273
3570274
3570281
3570282
3570283
6554
7979878
A_23_P25698
GE57674
GO:0001618
GO:0005215
GO:0005515
GO:0005886
GO:0006811
GO:0006814
GO:0006869
GO:0008508
GO:0014070
GO:0015125
GO:0015293
GO:0015721
GO:0016020
GO:0016323
GO:0023052
GO:0031667
GO:0038183
GO:0043627
GO:0045471
GO:0046718
GO:0055085
GO:0071466
GO:0120188
HMNXSV003015747
ILMN_1776112
L21893_at
PH_hs_0000124
TC14001263.hg
g4506970_3p_at
Inferred To
SLC10A1 [plasma membrane]
(Bos taurus)
SLC10A1 [plasma membrane]
(Caenorhabditis elegans)
SLC10A1 [plasma membrane]
(Canis familiaris)
SLC10A1 [plasma membrane]
(Sus scrofa)
Slc10a1 [plasma membrane]
(Mus musculus)
Slc10a1 [plasma membrane]
(Rattus norvegicus)
Homologues of SLC10A1 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG11655 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG9903 [plasma membrane]
(Drosophila melanogaster)
slc10a1 [plasma membrane]
(Danio rerio)
slc10a1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003040.1
ZINC - World Drugs
NTCP_HUMAN
Guide to Pharmacology - Targets
959
OpenTargets
ENSG00000100652
ZINC - FDA approved
NTCP_HUMAN
ZINC - Substances
NTCP_HUMAN
ZINC target
Q14973
ZINC - Biogenic
NTCP_HUMAN
PRO
Q14973
PDB
7ZYI
,
7WSI
,
7PQG
,
7VAG
,
7PQQ
,
8HRY
,
7VAD
,
8HRX
,
7FCI
,
8RQF
ZINC - Metabolites
NTCP_HUMAN
HPA
ENSG00000100652-SLC10A1
GeneCards
Q14973
Ensembl
ENSG00000100652
,
ENSP00000216540
,
ENST00000216540
Pharos - Targets
Q14973
ZINC - Predictions - Purchasable
NTCP_HUMAN
Orphanet
25425
HMDB Protein
HMDBP02550
Interactors (91)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.556
3
UniProt:Q6ZPD8 DGAT2L6
1
DGAT2L6 [endoplasmic reticulum membrane]
(R-HSA-8848588)
0.556
3
UniProt:Q99519 NEU1
8
NEU1 W23* [lysosomal lumen]
(R-HSA-5674155)
NEU1 W29* [lysosomal lumen]
(R-HSA-5674174)
NEU1 E377* [lysosomal lumen]
(R-HSA-5674181)
NEU1 R225P [lysosomal lumen]
(R-HSA-5674167)
NEU1 L303P [lysosomal lumen]
(R-HSA-5674182)
NEU1 [extracellular region]
(R-HSA-6806158)
NEU1 [specific granule lumen]
(R-HSA-6806148)
NEU1 [lysosomal lumen]
(R-HSA-1605788)
0.556
3
UniProt:Q5RI15 COX20
1
COX20 [mitochondrial inner membrane]
(R-HSA-5336169)
0.556
3
UniProt:Q99437 ATP6V0B
3
ATP6V0B [endosome membrane]
(R-HSA-912584)
ATP6V0B [phagocytic vesicle membrane]
(R-HSA-1222695)
ATP6V0B [lysosomal membrane]
(R-HSA-9640187)
0.556
3
UniProt:P06681 C2
3
C2b [extracellular region]
(R-HSA-166781)
C2 [extracellular region]
(R-HSA-166778)
C2a [extracellular region]
(R-HSA-166780)
0.556
3
UniProt:Q13021 MALL
0.556
3
UniProt:Q9H2L4 TMM60
0.556
3
UniProt:Q14802-3 FXYD3
0.556
3
UniProt:P11836 CD20
0.556
3
UniProt:Q99640-2 PKMYT1
0.556
3
UniProt:Q9Y666-2 SLC12A7
0.556
3
UniProt:Q7Z4F1 LRP10
1
LRP10 [plasma membrane]
(R-HSA-2424275)
0.556
3
UniProt:Q9BSR8 YIPF4
0.556
3
UniProt:Q96B49 TOMM6
1
TOMM6 [mitochondrial outer membrane]
(R-HSA-1252171)
0.556
3
UniProt:Q8WW34-2 TMEM239
0.556
3
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.556
3
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q5TGU0 TSPO2
0.556
3
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.556
3
UniProt:Q8N138 ORMDL3
4
ORMDL3 [specific granule membrane]
(R-HSA-6799643)
ORMDL3 [plasma membrane]
(R-HSA-6806293)
ORMDL3 [secretory granule membrane]
(R-HSA-6800882)
ORMDL3 [endoplasmic reticulum membrane]
(R-HSA-8865589)
0.556
3
UniProt:A5PKU2 A5PKU2
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q9BTD3 TM121
0.556
3
UniProt:Q8WV19 SFT2A
0.556
3
UniProt:Q9H0Q3 FXYD6
1
FXYD6 [plasma membrane]
(R-HSA-2752104)
0.556
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.556
3
UniProt:Q6IBB0 Q6IBB0
0.556
3
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.556
3
UniProt:Q6ICL7 S35E4
0.556
3
UniProt:Q9NWH2 TM242
0.556
3
UniProt:Q96D05-2 FAM241B
0.556
3
UniProt:Q969X1 TMBIM1
2
TMBIM1 [specific granule membrane]
(R-HSA-6799704)
TMBIM1 [plasma membrane]
(R-HSA-6800472)
0.556
3
UniProt:Q96AG3 S2546
0.556
3
UniProt:O60906 SMPD2
1
SMPD2 [plasma membrane]
(R-HSA-194337)
0.556
3
UniProt:Q7RTS5 OTOP3
0.556
3
UniProt:Q9H2H9 SLC38A1
1
SLC38A1 [plasma membrane]
(R-HSA-212663)
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:P00387 CYB5R3
3
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
0.556
3
UniProt:Q9NRZ7 AGPAT3
2
AGPAT3 [Golgi membrane]
(R-HSA-8849239)
AGPAT3 [endoplasmic reticulum membrane]
(R-HSA-61807)
0.556
3
UniProt:P21145 MAL
0.556
3
UniProt:P01350 GAST
1
GAST(76-92) [extracellular region]
(R-HSA-870266)
0.556
3
UniProt:Q96MX0 CKLF3
0.556
3
UniProt:P48449 LSS
1
LSS [endoplasmic reticulum membrane]
(R-HSA-191371)
0.556
3
UniProt:Q9H9B4 SFXN1
0.556
3
UniProt:Q8N6S5 AR6P6
0.556
3
UniProt:Q8WY07 SLC7A3
1
SLC7A3 [plasma membrane]
(R-HSA-375779)
0.556
3
UniProt:Q8N6F1-2 CLDN19
0.556
3
UniProt:Q9H0R3 TM222
0.556
3
UniProt:A0PK00 T120B
0.556
3
UniProt:Q8WY98 TM234
0.556
3
UniProt:Q96FB2 Q96FB2
0.556
3
UniProt:Q53FV1 ORMDL2
1
ORMDL2 [endoplasmic reticulum membrane]
(R-HSA-8865591)
0.556
3
UniProt:Q03518 TAP1
3
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
0.556
3
UniProt:O95562 SFT2B
0.556
3
UniProt:O15400 STX7
0.556
3
UniProt:A6NDP7 MADL2
0.556
3
UniProt:Q969E2 SCAM4
0.556
3
UniProt:Q53HI1 UNC50
0.556
3
UniProt:Q9BXR6 CFHR5
1
CFHR5 [extracellular region]
(R-HSA-8851419)
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:Q8IVJ1 SLC41A1
1
SLC41A1 [plasma membrane]
(R-HSA-442659)
0.556
3
UniProt:I3L0A0 I3L0A0
0.556
3
UniProt:P07306 ASGR1
1
PALM-C36-ASGR1 [plasma membrane]
(R-HSA-8855714)
0.556
3
UniProt:Q9Y5Y5 PEX16
2
PEX16 [peroxisomal membrane]
(R-HSA-9603805)
PEX16 [cytosol]
(R-HSA-9603790)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:Q01628 IFITM3
1
IFITM3 [plasma membrane]
(R-HSA-1015688)
0.556
3
UniProt:O95393 BMP10
2
BMP10(22-424) [extracellular region]
(R-HSA-2396409)
BMP10 [extracellular region]
(R-HSA-8858374)
0.556
3
UniProt:Q9Y6D0 SELK
0.556
3
UniProt:O95870 ABHGA
0.556
3
UniProt:Q96GQ5 RUSF1
0.556
3
IntAct:EBI-23343277 CCSB ORF ID
0.556
3
UniProt:Q9ULC5 ACSL5
1
ACSL5 [endoplasmic reticulum membrane]
(R-HSA-165011)
0.556
3
UniProt:Q07325 CXCL9
1
CXCL9 [extracellular region]
(R-HSA-373856)
0.556
3
UniProt:P02786 TFRC
5
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
0.556
3
UniProt:Q9P0S3 ORMDL1
1
ORMDL1 [endoplasmic reticulum membrane]
(R-HSA-8865584)
0.556
3
UniProt:Q96IV6 FXDC2
0.556
3
UniProt:Q7L5A8 FA2H
1
FA2H [endoplasmic reticulum membrane]
(R-HSA-5693771)
0.556
3
UniProt:Q9NYZ1 TV23B
0.556
3
IntAct:EBI-23683896 CCSB ORF ID
0.556
3
UniProt:Q6ZSS7 MFSD6
0.556
3
UniProt:P07357 C8A
1
C8A [extracellular region]
(R-HSA-173716)
0.556
3
UniProt:Q71RG4 TMUB2
0.556
3
UniProt:Q9NVC3 S38A7
0.556
3
UniProt:Q8N2U9 S66A2
0.556
3
UniProt:Q9NZC3 GDE1
1
GDE1 [plasma membrane]
(R-HSA-1498746)
0.556
3
UniProt:Q9NZG7 NINJ2
0.556
3
UniProt:Q7RTY0 MOT13
0.556
3
UniProt:Q9BVK8 TM147
0.556
3
UniProt:P0DTD3 ORF9C
0.488
2
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