Reactome | ABCA1 [plasma membrane]

ABCA1 [plasma membrane]

Stable Identifier

R-HSA-194209

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP-binding cassette sub-family A member 1

Icon

Locations in the PathwayBrowser for interactor UniProt:O75955 FLOT1

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External Reference Information

External Reference

UniProt:O95477 ABCA1

Gene Names

ABCA1, ABC1, CERP

Chain

chain:1-2261

Reference Genes

BioGPS Gene:19 ABCA1

COSMIC (genes):ABCA1 ABCA1

CTD Gene:19 ABCA1

dbSNP Gene:19 ABCA1

ENSEMBL:ENSG00000165029 ABCA1

HGNC:29 ABCA1

KEGG:hsa:19 ABCA1

Monarch:19 ABCA1

NCBI Gene:19 ABCA1

OMIM:600046 ABCA1

UCSC:O95477 ABCA1

Reference Transcript

RefSeq:NM_005502.3 ABCA1

Other Identifiers

11739502_a_at

11739503_at

1570279_PM_at

1570279_at

17096728

203504_PM_s_at

203504_s_at

203505_PM_at

216066_PM_at

216066_at

31998_at

32000_g_at

3218529

3218530

3218531

3218532

3218533

3218535

3218537

3218538

3218539

3218543

3218544

3218545

3218547

3218548

3218549

3218552

3218553

3218554

3218557

3218558

3218559

3218560

3218563

3218564

3218566

3218567

3218568

3218570

3218574

3218575

3218576

3218578

3218579

3218582

3218583

3218584

3218585

3218586

3218587

3218588

3218589

3218590

3218591

3218594

3218595

3218596

3218597

3218598

3218604

3218606

3218608

3218609

3218612

3218617

3218618

3218620

3218622

3218623

3218624

3218628

3218629

3218633

3218639

3218640

3218655

3218656

3218657

52656_s_at

60496_r_at

78253_r_at

8162940

A_23_P216649

A_24_P235429

A_24_P289265

A_33_P3422897

GE61476

GO:0002790

GO:0003824

GO:0005102

GO:0005215

GO:0005515

GO:0005524

GO:0005548

GO:0005768

GO:0005789

GO:0005794

GO:0005886

GO:0006629

GO:0006869

GO:0006911

GO:0007040

GO:0007186

GO:0007189

GO:0007584

GO:0008035

GO:0008203

GO:0008289

GO:0008320

GO:0009306

GO:0009410

GO:0009897

GO:0009986

GO:0010745

GO:0010875

GO:0010887

GO:0015485

GO:0015914

GO:0016020

GO:0016192

GO:0016197

GO:0016323

GO:0016787

GO:0016887

GO:0019905

GO:0023061

GO:0030139

GO:0030301

GO:0031210

GO:0031267

GO:0031410

GO:0031667

GO:0032367

GO:0032489

GO:0033344

GO:0033552

GO:0033700

GO:0034185

GO:0034186

GO:0034188

GO:0034380

GO:0034616

GO:0038024

GO:0038027

GO:0042157

GO:0042158

GO:0042626

GO:0042632

GO:0043226

GO:0043231

GO:0043691

GO:0045121

GO:0045332

GO:0045335

GO:0046623

GO:0048471

GO:0051117

GO:0051649

GO:0055085

GO:0055091

GO:0060089

GO:0060155

GO:0061024

GO:0065003

GO:0071222

GO:0071300

GO:0071345

GO:0071397

GO:0071404

GO:0071466

GO:0071806

GO:0090107

GO:0090108

GO:0090554

GO:0090556

GO:0097708

GO:0099039

GO:0120020

GO:0140115

GO:0140326

GO:0140328

GO:0140359

GO:0140657

HMNXSV003009990

HMNXSV003017214

HMNXSV003051456

Hs.211562.1.S1_3p_at

Hs2.407188.1.S1_3p_at

ILMN_1766054

PH_hs_0022625

TC09001434.hg

g5915657_3p_a_at

g9755158_3p_at

Participates

as a component of

as an input of

NR1H2 binds ABCA1 (Homo sapiens)

as an output of

Other forms of this molecule

4xPALM-C-p-2S-ABCA1 [plasma membrane]

4xPALM-C-ABCA1 [endoplasmic reticulum membrane]

4xPALM-C-ABCA1 [plasma membrane]

ABCA1 [endoplasmic reticulum membrane]

ABCA1 Q537R [plasma membrane]

ABCA1 R587W [plasma membrane]

ABCA1 S1446L [plasma membrane]

ABCA1 C1417R [plasma membrane]

ABCA1 N935S [plasma membrane]

ABCA1 W590S [plasma membrane]

Inferred To

CG8473 [plasma membrane] (Drosophila melanogaster)

ABCA1 [plasma membrane] (Bos taurus)

ABCA1 [plasma membrane] (Canis familiaris)

ABCA1 [plasma membrane] (Dictyostelium discoideum)

ABCA1 [plasma membrane] (Gallus gallus)

ABCA1 [plasma membrane] (Mus musculus)

ABCA1 [plasma membrane] (Plasmodium falciparum)

ABCA1 [plasma membrane] (Sus scrofa)

abt-1 [plasma membrane] (Caenorhabditis elegans)

Abca1 [plasma membrane] (Rattus norvegicus)

abca1 [plasma membrane] (Xenopus tropicalis)

Homologues of ABCA1 [plasma membrane] (Dictyostelium discoideum)

Homologues of ABCA1 [plasma membrane] (Drosophila melanogaster)

abca1a [plasma membrane] (Danio rerio)

ldd [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

756

OpenTargets

ENSG00000165029

ENSEMBL

ENST00000374736, ENSP00000363868

IntEnz

7.6.2.1

HPA

ENSG00000165029-ABCA1

PRO

O95477

Pharos - Targets

O95477

GlyGen

O95477

Orphanet

ABCA1

HMDB Protein

HMDBP01618

PDB

7ROQ, 7TDT, 7TC0, 7TBY, 7TBZ, 7TBW, 5XJY

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.621	8
UniProt:Q86UK0 ABCA12	6	ABCA12 V2442Sfs22 [plasma membrane] (R-HSA-5682350) ABCA12 K1671Ifs4 [plasma membrane] (R-HSA-5682320) ABCA12 D2363N [plasma membrane] (R-HSA-5682291) ABCA12 R287* [plasma membrane] (R-HSA-5682308) ABCA12 G1179R [plasma membrane] (R-HSA-5682356) ABCA12 [plasma membrane] (R-HSA-383202)	0.589	4
UniProt:Q13884 SNTB1	1	SNTB1 [plasma membrane] (R-HSA-5490333)	0.576	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.576	8
UniProt:Q86Y82 STX12			0.537	9
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.527	3
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.524	2
UniProt:Q13425 SNTB2	1	SNTB2 [plasma membrane] (R-HSA-9630713)	0.508	3
UniProt:Q13424 SNTA1	1	SNTA1 [plasma membrane] (R-HSA-5490334)	0.499	2
UniProt:O75955 FLOT1	1	FLOT1 [plasma membrane] (R-HSA-112174)	0.499	2