Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SMPD2 [plasma membrane]
Stable Identifier
R-HSA-194337
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingomyelin phosphodiesterase 2, NSMA_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O15173%20PGRC2
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Ceramide signalling (Homo sapiens)
Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)
SMPD2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60906 SMPD2
Gene Names
SMPD2
Chain
chain:1-423
Reference Genes
BioGPS Gene:6610 SMPD2
COSMIC (genes):SMPD2 SMPD2
CTD Gene:6610 SMPD2
dbSNP Gene:6610 SMPD2
ENSEMBL:ENSG00000135587 SMPD2
ENSEMBL_homo_sapiens_GENE:ENSG00000135587.9 SMPD2
HGNC:11121 SMPD2
KEGG Gene (Homo sapiens):6610 SMPD2
Monarch:6610 SMPD2
NCBI Gene:6610 SMPD2
OMIM:603498 SMPD2
UCSC:O60906 SMPD2
Reference Transcript
RefSeq:NM_003080.2 SMPD2
Other Identifiers
11723772_at
17011572
205622_PM_at
205622_at
2920917
2920918
2920919
2920920
2920922
2920924
2920925
2920927
2920928
2920930
2920931
2920932
2920934
2920935
2920936
41798_at
6610
8121418
A_14_P117845
A_23_P82162
GE55239
GO:0003824
GO:0004767
GO:0005515
GO:0005783
GO:0005886
GO:0005901
GO:0006629
GO:0006665
GO:0006684
GO:0006685
GO:0008081
GO:0016020
GO:0016787
GO:0030149
GO:0043226
GO:0046513
GO:0046872
GO:0071944
HMNXSV003050777
ILMN_1672176
PH_hs_0027128
TC06000876.hg
g4507094_3p_at
Participates
as a member of
SMPD2,3 [plasma membrane] (Homo sapiens)
as an input of
Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)
as a component of
Active N-SMase:Mg2+ [plasma membrane] (Homo sapiens)
Inferred To
NSMase [plasma membrane]
(Danio rerio)
SMPD2 [plasma membrane]
(Caenorhabditis elegans)
SMPD2 [plasma membrane]
(Canis familiaris)
SMPD2 [plasma membrane]
(Drosophila melanogaster)
SMPD2 [plasma membrane]
(Gallus gallus)
SMPD2 [plasma membrane]
(Mus musculus)
SMPD2 [plasma membrane]
(Rattus norvegicus)
SMPD2 [plasma membrane]
(Saccharomyces cerevisiae)
SMPD2 [plasma membrane]
(Schizosaccharomyces pombe)
SMPD2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_003071.2
Guide to Pharmacology - Targets
2515
OpenTargets
ENSG00000135587
ZINC - Substances
NSMA_HUMAN
GeneCards
O60906
HPA
ENSG00000135587-SMPD2
ZINC target
O60906
Ensembl
ENSG00000135587
,
ENST00000258052
,
ENSP00000258052
PRO
O60906
Pharos - Targets
O60906
ZINC - Predictions - Purchasable
NSMA_HUMAN
HMDB Protein
HMDBP01090
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y371 SHLB1
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:Q9ULP0-2 NDRG4
0.556
3
UniProt:Q9UKF7-2 PITPNC1
0.556
3
UniProt:O00622 CYR61
2
p-CYR61 [endoplasmic reticulum lumen]
(R-HSA-8956919)
CYR61 [endoplasmic reticulum lumen]
(R-HSA-5173201)
0.556
3
UniProt:Q9UHI5 SLC7A8
1
SLC7A8 [plasma membrane]
(R-HSA-352156)
0.556
3
UniProt:Q96AL5 Q96AL5
0.556
3
UniProt:Q9NRX6 KISHB
0.556
3
UniProt:Q8NI60 COQ8A
1
COQ8A [mitochondrial inner membrane]
(R-HSA-9856284)
0.556
3
UniProt:P53367 ARFP1
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.556
3
UniProt:P49675 STAR
2
STAR [mitochondrial matrix]
(R-HSA-9838092)
STAR [mitochondrial intermembrane space]
(R-HSA-196120)
0.556
3
UniProt:Q05329 GAD2
2
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888582)
PXLP-K396-GAD2 [plasma membrane]
(R-HSA-936509)
0.556
3
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text