Reactome | YWHAE [cytosol]

YWHAE [cytosol]

Stable Identifier

R-HSA-194368

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 protein epsilon, 143E_HUMAN, 14-3-3 epsilon

Locations in the PathwayBrowser for interactor UniProt:Q86Z20 CC125

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External Reference Information

External Reference

UniProt:P62258 YWHAE

Gene Names

YWHAE

Chain

chain:1-255

Reference Genes

BioGPS Gene:7531 YWHAE

COSMIC (genes):YWHAE YWHAE

CTD Gene:7531 YWHAE

dbSNP Gene:7531 YWHAE

ENSEMBL:ENSG00000108953 YWHAE

ENSEMBL:ENSG00000274474 YWHAE

HGNC:12851 YWHAE

KEGG Gene (Homo sapiens):7531 YWHAE

Monarch:7531 YWHAE

NCBI Gene:7531 YWHAE

OMIM:605066 YWHAE

UCSC:P62258 YWHAE

Reference Transcript

RefSeq:NM_006761.4 YWHAE

Other Identifiers

0001240019

1011_s_at

11739011_s_at

11753092_s_at

11753517_s_at

11753518_x_at

11758309_s_at

16200

210317_s_at

210996_s_at

21109

2578538

2BR9

3052111

3052117

3740125

3740127

3740128

3740129

3740130

3740131

3740132

3740133

3740134

3740135

3740139

3740141

3740143

3740144

3740147

3740148

3740149

3740156

3740157

3740158

3752151

3UAL

3UBW

47350

6EIH

7531

8011011

8055476

8445

A_23_P72285

A_24_P123011

A_24_P123012

AAA75301

AAC50175

AAC50625

AAC50710

AAD00026

AAH00179

AAH01440

AAP35825

AAX68683

AB017103

ACJ13635

AK128785

AK295260

AK316185

AY883089

B4DJF2

BAA32538

BAG54733

BAG58249

BAH14556

BC000179

BC001440

BT007161

CAB016200

CAB021109

CAB047350

CCDS11001

CH471108

EAW90628

EAW90629

ENSG00000108953

ENSG00000274474

ENSP00000264335

ENSP00000461762

ENSP00000481059

ENSP00000487356

ENST00000264335

ENST00000264335.12

ENST00000571732

ENST00000571732.5

ENST00000616643

ENST00000627231

EntrezGene:7531

EntrezGene:YWHAE

EU794581

g4096984_3p_a_at

g984318_3p_a_at

GE59242

GO:0000086

GO:0000165

GO:0000278

GO:0001764

GO:0003013

GO:0003064

GO:0003674

GO:0003723

GO:0005246

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005871

GO:0005886

GO:0005925

GO:0006464

GO:0006605

GO:0006810

GO:0006913

GO:0006950

GO:0007005

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0010389

GO:0015031

GO:0015459

GO:0016020

GO:0016032

GO:0019899

GO:0019904

GO:0021762

GO:0021766

GO:0021987

GO:0022607

GO:0023026

GO:0030154

GO:0030424

GO:0031410

GO:0031625

GO:0032991

GO:0034504

GO:0034605

GO:0035308

GO:0035329

GO:0035556

GO:0040011

GO:0042470

GO:0042592

GO:0042802

GO:0042826

GO:0043154

GO:0043226

GO:0044325

GO:0044403

GO:0044877

GO:0045202

GO:0045296

GO:0046827

GO:0046982

GO:0048856

GO:0048870

GO:0050815

GO:0051219

GO:0051480

GO:0055085

GO:0060306

GO:0061024

GO:0070062

GO:0086013

GO:0086091

GO:0090724

GO:0097110

GO:0097711

GO:0098978

GO:0099072

GO:1900034

GO:1900740

GO:1901016

GO:1901020

GO:1902309

GO:1905913

HEL2

HGNC:12851

HPA008445

I3L0W5

I3L3T1

ILMN_1807535

ILMN_2252136

IPR000308

IPR023409

IPR023410

IPR036815

K7EM20

MIM:605066

NM_006761

NP_006752

NR_024058

PF00244

PH_hs_0029000

PH_hs_0031355

PR00305

SM00101

TC17000972.hg

TC17002434.hg

U20972

U28936

U43399

U43430

U54778

U54778_at

UPI0000021A46

UPI00001E6021

V9HW98

XM_005256784

XM_017025005

XP_005256841

XP_016880494

YWHAE

YWHAE-201

YWHAE-208

YWHAE-214

YWHAE-217

Participant Of

hasComponent

input

CDC25C binds YWHAE (14-3-3-epsilon)

Inferred To

Ghost homologue of YWHAE [cytosol] (Gallus gallus)

rad24 [cytosol] (Schizosaccharomyces pombe)

ywhae1 [cytosol] (Danio rerio)

14-3-3 epsilon [cytosol] (Mus musculus)

Ywhae [cytosol] (Rattus norvegicus)

ywhae [cytosol] (Xenopus tropicalis)

BMH2 [cytosol] (Saccharomyces cerevisiae)

CRK [cytosol] (Sus scrofa)

YWHAE [cytosol] (Bos taurus)

YWHAE [cytosol] (Canis familiaris)

YWHAE [cytosol] (Plasmodium falciparum)

fttB [cytosol] (Dictyostelium discoideum)

14-3-3epsilon [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_006752.1

Target Pathogen

5b354852be737e166372e6ba

OpenTargets

ENSG00000108953

HPA

ENSG00000108953-YWHAE

GeneCards

P62258

Ensembl

ENST00000571732, ENSP00000264335, ENSG00000274474, ENST00000264335, ENSP00000487356, ENST00000616643, ENSP00000481059, ENSP00000461762, ENSG00000108953, ENST00000627231

PRO

P62258

Orphanet

20276

PDB

3UAL, 2BR9, 6EIH, 3UBW

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.864	9
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.84	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.831	7
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.823	8
UniProt:P54253 ATX1			0.786	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.764	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.738	5
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.738	4
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.738	5
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.708	5
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.69	5
UniProt:P35568 IRS1	5	p-Y-IRS1 [cytosol] (R-HSA-74772) p-Y-IRS1 [plasma membrane] (R-HSA-198366) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.682	6
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.669	3
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.669	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.667	3
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.667	4
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.659	3
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.659	3
UniProt:Q99469 STAC			0.656	3
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.643	4
UniProt:Q9Y3M2 CBY1	3	CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [nucleoplasm] (R-HSA-3769356) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.638	4
UniProt:O92972-PRO_0000278742			0.625	5
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.621	3
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.612	5
UniProt:Q9Y2U5 M3K2			0.602	3
UniProt:Q14678-2 KANK1			0.602	3
UniProt:P30305 CDC25B	3	CDC25B [cytosol] (R-HSA-157412) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [nucleoplasm] (R-HSA-69734)	0.573	3
UniProt:P58340 MLF1			0.558	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q06251 YL177			0.556	3
UniProt:Q7L804 RAB11FIP2	1	RAB11FIP2 [cytoplasmic vesicle membrane] (R-HSA-2028707)	0.556	3
UniProt:P56524-2 HDAC4			0.556	3
UniProt:Q08981 ACM1			0.556	3
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.547	2
UniProt:Q13111 CAF1A			0.547	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.547	3
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.545	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.544	3
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.527	2
UniProt:O43900 PRIC3			0.527	2
UniProt:Q9UJM3 ERRFI			0.527	2
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.527	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q02750 MAP2K1	7	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.527	3
UniProt:Q61337 Bad	6	Bad [mitochondrial outer membrane] (R-MMU-114242) phospho-Bad [cytosol] (R-MMU-217297) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) phospho-Bad [cytosol] (R-MMU-198335) Bad [cytosol] (R-MMU-50662)	0.527	2
UniProt:P22681 CBL	6	p-Y371-CBL [cytosol] (R-HSA-182940) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.527	2
UniProt:P00519 ABL1	5	ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.527	2
UniProt:O35244	3	Prdx6 [extracellular region] (R-RNO-6806198) Prdx6 [cytosol] (R-RNO-3343670) Prdx6 [azurophil granule lumen] (R-RNO-6798744)	0.524	2
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	3
UniProt:O94921 CDK14			0.508	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q5SW79 CE170			0.508	2
UniProt:Q9NRR6 INPP5E	2	INPP5E [cytosol] (R-HSA-1604585) INPP5E [cilium] (R-HSA-5624872)	0.508	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.508	3
UniProt:O00257-3 CBX4			0.499	2
UniProt:P09622 DLD	1	DLD [mitochondrial matrix] (R-HSA-69978)	0.499	5
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.499	4
UniProt:P21796 VDAC1	4	VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960)	0.499	5
UniProt:Q51451 Q51451			0.469	2
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [cytosol] (R-HSA-3343670) PRDX6 [azurophil granule lumen] (R-HSA-6798744)	0.463	2
UniProt:Q76353 Q76353			0.462	2
UniProt:P26045 PTPN3	1	PTPN3 [plasma membrane] (R-HSA-5490317)	0.462	2
UniProt:P51957-2 NEK4			0.462	2
UniProt:P51957-1 NEK4			0.462	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3