Reactome | YWHAE [cytosol]

YWHAE [cytosol]

Stable Identifier

R-HSA-194368

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 protein epsilon, 143E_HUMAN, 14-3-3 epsilon

Locations in the PathwayBrowser for interactor UniProt:Q86Z20 CC125

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External Reference Information

External Reference

UniProt:P62258 YWHAE

Gene Names

YWHAE

Chain

chain:1-255

Reference Genes

BioGPS Gene:7531 YWHAE

COSMIC (genes):YWHAE YWHAE

CTD Gene:7531 YWHAE

dbSNP Gene:7531 YWHAE

ENSEMBL:ENSG00000108953 YWHAE

ENSEMBL:ENSG00000274474 YWHAE

HGNC:12851 YWHAE

KEGG Gene (Homo sapiens):7531 YWHAE

Monarch:7531 YWHAE

NCBI Gene:7531 YWHAE

OMIM:605066 YWHAE

UCSC:P62258 YWHAE

Reference Transcript

RefSeq:NM_006761.4 YWHAE

Other Identifiers

0001240019

1011_s_at

11739011_s_at

11753092_s_at

11753517_s_at

11753518_x_at

11758309_s_at

210317_s_at

210996_s_at

2578538

3052111

3052117

3740125

3740127

3740128

3740129

3740130

3740131

3740132

3740133

3740134

3740135

3740139

3740141

3740143

3740144

3740147

3740148

3740149

3740156

3740157

3740158

3752151

7531

8011011

8055476

A_23_P72285

A_24_P123011

A_24_P123012

GE59242

GO:0000086

GO:0000165

GO:0000278

GO:0001764

GO:0003013

GO:0003064

GO:0003674

GO:0003723

GO:0005246

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005871

GO:0005886

GO:0005925

GO:0006464

GO:0006605

GO:0006810

GO:0006913

GO:0006950

GO:0007005

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0010389

GO:0015031

GO:0015459

GO:0016020

GO:0016032

GO:0019899

GO:0019903

GO:0019904

GO:0021762

GO:0021766

GO:0021987

GO:0022607

GO:0023026

GO:0030154

GO:0030424

GO:0031410

GO:0031625

GO:0032991

GO:0034504

GO:0034605

GO:0035308

GO:0035329

GO:0035556

GO:0040011

GO:0042470

GO:0042592

GO:0042802

GO:0042826

GO:0043154

GO:0043226

GO:0044325

GO:0044403

GO:0044877

GO:0045296

GO:0046827

GO:0046982

GO:0048856

GO:0048870

GO:0050815

GO:0051219

GO:0051480

GO:0055085

GO:0060306

GO:0061024

GO:0070062

GO:0086013

GO:0086091

GO:0090724

GO:0097110

GO:0097711

GO:0098978

GO:0099072

GO:1900034

GO:1900740

GO:1901016

GO:1901020

GO:1902309

GO:1905913

ILMN_1807535

ILMN_2252136

PH_hs_0029000

PH_hs_0031355

TC17000972.hg

TC17002434.hg

U54778_at

g4096984_3p_a_at

g984318_3p_a_at

Participant Of

hasComponent

input

CDC25C binds YWHAE (14-3-3-epsilon)

Inferred To

Ghost homologue of YWHAE [cytosol] (Canis familiaris)

Ghost homologue of YWHAE [cytosol] (Gallus gallus)

rad24 [cytosol] (Schizosaccharomyces pombe)

ywhae2 [cytosol] (Danio rerio)

ywhae1 [cytosol] (Danio rerio)

14-3-3 epsilon [cytosol] (Mus musculus)

Ywhae [cytosol] (Rattus norvegicus)

BMH2 [cytosol] (Saccharomyces cerevisiae)

rrnad1 [cytosol] (Xenopus tropicalis)

YWHAE [cytosol] (Plasmodium falciparum)

YWHAE [cytosol] (Sus scrofa)

fttB [cytosol] (Dictyostelium discoideum)

14-3-3epsilon [cytosol] (Drosophila melanogaster)

Homologues of YWHAE [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006752.1

Target Pathogen

5b354852be737e166372e6ba

OpenTargets

ENSG00000108953

GeneCards

P62258

HPA

ENSG00000108953-YWHAE

Ensembl

ENSG00000274474, ENSP00000264335, ENSP00000487356, ENST00000627231, ENSG00000108953, ENST00000616643, ENSP00000481059, ENSP00000461762, ENST00000264335, ENST00000571732

PRO

P62258

Orphanet

20276

PDB

3UAL, 3UBW, 2BR9, 6EIH

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.864	9
UniProt:P54253 ATX1			0.853	13
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.84	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.831	7
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.823	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.764	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.738	5
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.738	4
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.738	5
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.708	5
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.69	5
UniProt:P35568 IRS1	5	p-Y-IRS1 [cytosol] (R-HSA-74772) p-Y-IRS1 [plasma membrane] (R-HSA-198366) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.682	6
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.669	3
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.669	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.667	3
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.667	4
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.659	3
UniProt:Q9GZV5 WWTR1	3	WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.659	3
UniProt:Q99469 STAC			0.656	3
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.643	4
UniProt:Q9Y3M2 CBY1	3	CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [nucleoplasm] (R-HSA-3769356) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.638	4
UniProt:O92972-PRO_0000278742			0.625	5
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.621	3
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.612	5
UniProt:Q9Y2U5 M3K2			0.602	3
UniProt:Q14678-2 KANK1			0.602	3
UniProt:P30305 CDC25B	3	CDC25B [cytosol] (R-HSA-157412) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [nucleoplasm] (R-HSA-69734)	0.573	3
UniProt:P58340 MLF1			0.558	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q06251 YL177			0.556	3
UniProt:Q7L804 RAB11FIP2	1	RAB11FIP2 [cytoplasmic vesicle membrane] (R-HSA-2028707)	0.556	3
UniProt:P56524-2 HDAC4			0.556	3
UniProt:Q08981 ACM1			0.556	3
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.547	2
UniProt:Q13111 CAF1A			0.547	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.547	3
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.545	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.544	3
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.527	2
UniProt:O43900 PRIC3			0.527	2
UniProt:Q9UJM3 ERRFI			0.527	2
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.527	3
UniProt:Q02750 MAP2K1	27	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 F53C [cytosol] (R-HSA-9652028) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 [cytosol] (R-HSA-59502) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.527	3
UniProt:Q61337 Bad	6	Bad [mitochondrial outer membrane] (R-MMU-114242) phospho-Bad [cytosol] (R-MMU-217297) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) phospho-Bad [cytosol] (R-MMU-198335) Bad [cytosol] (R-MMU-50662)	0.527	2
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.527	2
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.527	2
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:O35244	3	Prdx6 [azurophil granule lumen] (R-RNO-6798744) Prdx6 [extracellular region] (R-RNO-6806198) Prdx6 [cytosol] (R-RNO-3343670)	0.524	2
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.508	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	3
UniProt:Q9NRR6 INPP5E	2	INPP5E [cytosol] (R-HSA-1604585) INPP5E [cilium] (R-HSA-5624872)	0.508	3
UniProt:O94921 CDK14			0.508	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q5SW79 CE170			0.508	2
UniProt:O00257-3 CBX4			0.499	2
UniProt:P09622 DLD	1	DLD [mitochondrial matrix] (R-HSA-69978)	0.499	5
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.499	4
UniProt:P21796 VDAC1	4	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988)	0.499	5
UniProt:Q51451 Q51451			0.469	2
UniProt:P30041 PRDX6	3	PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [cytosol] (R-HSA-3343670)	0.463	2
UniProt:Q76353 Q76353			0.462	2
UniProt:P26045 PTPN3	3	p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317) PTPN3 [cytosol] (R-HSA-8867650)	0.462	2
UniProt:P51957-2 NEK4			0.462	2
UniProt:P51957-1 NEK4			0.462	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3

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