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p-T,Y-MAPK8 [cytosol]
Stable Identifier
R-HSA-194371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T,Y-JNK1, mitogen-activated protein kinase 8 (phosphorylated)
Icon
Locations in the PathwayBrowser for interactor UniProt:O14733 MAP2K7
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-38 signaling (Homo sapiens)
MAPK8 phosphorylation (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
GTP-bound RAC contributes to JNK activation (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
JNK phosphorylates BIM, BAD and other targets (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45983 MAPK8
Gene Names
MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Chain
chain:1-427
Reference Genes
COSMIC (genes):MAPK8 MAPK8
dbSNP Gene:5599 MAPK8
ENSEMBL:ENSG00000107643 MAPK8
Participates
as a member of
p-T,Y MAPK8,9 [cytosol] (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
as an input of
p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)
as an output of
GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
GTP-bound RAC contributes to JNK activation (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
MAPK8 phosphorylation (Homo sapiens)
Other forms of this molecule
MAPK8 [cytosol]
p-T,Y-MAPK8 [nucleoplasm]
Inferred To
phospho-p-T,Y-MAPK8 [cytosol]
(Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [cytosol]
(Danio rerio)
phospho-p-T,Y-MAPK8 [cytosol]
(Dictyostelium discoideum)
phospho-p-T,Y-MAPK8 [cytosol]
(Drosophila melanogaster)
phospho-p-T,Y-MAPK8 [cytosol]
(Mus musculus)
phospho-p-T,Y-MAPK8 [cytosol]
(Rattus norvegicus)
phospho-p-T,Y-MAPK8 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T,Y-MAPK8 [cytosol]
(Schizosaccharomyces pombe)
Homologues of p-T,Y-MAPK8 [cytosol]
(Dictyostelium discoideum)
phospho-MAPK8 [cytosol]
(Bos taurus)
phospho-MAPK8 [cytosol]
(Canis familiaris)
phospho-MAPK8 [cytosol]
(Gallus gallus)
phospho-MAPK8 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.854
5
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.773
5
UniProt:Q9UQF2 JIP1
0.708
8
UniProt:P45985 MAP2K4
4
MAP2K4(?-399) [cytosol]
(R-HSA-5211396)
MAP2K4(1-?) [cytosol]
(R-HSA-5211402)
p-S257,T261-MAP2K4 [cytosol]
(R-HSA-168170)
MAP2K4 [cytosol]
(R-HSA-168107)
0.688
3
UniProt:Q13202 DUSP8
2
DUSP8 [nucleoplasm]
(R-HSA-5675349)
DUSP8 [cytosol]
(R-HSA-5675348)
0.659
3
UniProt:O43379 WDR62
0.643
3
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.623
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:O14733-2 MAP2K7
0.544
3
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.536
2
UniProt:P29401 TKT
1
TKT [cytosol]
(R-HSA-71321)
0.527
2
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.524
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.516
2
UniProt:Q8N122 RPTOR
3
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [cytosol]
(R-HSA-3006727)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.499
6
UniProt:Q9WVI9-1 MAPK8IP1
0.499
2
UniProt:P56747 CLDN6
2
CLDN6 [plasma membrane]
(R-HSA-419992)
CLDN6 [cell junction]
(R-HSA-421250)
0.488
3
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.483
4
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.483
2
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