Reactome | NGFR(273-427) [cytosol]

NGFR(273-427) [cytosol]

Stable Identifier

R-HSA-194458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p75NTR intracellular domain, Tumor necrosis factor receptor superfamily member 16, TR16_HUMAN, NGFR

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08138 NGFR

Gene Names

NGFR, TNFRSF16

Chain

signal peptide:1-28, chain:29-427

Reference Genes

BioGPS Gene:4804 NGFR

COSMIC (genes):NGFR NGFR

CTD Gene:4804 NGFR

dbSNP Gene:4804 NGFR

ENSEMBL:ENSG00000064300 NGFR

ENSEMBL:ENSG00000064300.9 NGFR

HGNC:7809 NGFR

KEGG Gene (Homo sapiens):4804 NGFR

Monarch:4804 NGFR

NCBI Gene:4804 NGFR

OMIM:162010 NGFR

UCSC:P08138 NGFR

Reference Transcript

RefSeq:NM_002507.3 NGFR

Other Identifiers

11723398_at

11747159_a_at

1673_at

16835592

205858_PM_at

205858_at

3725686

3725687

3725694

3725699

3725702

3725705

3725706

3725707

3725708

4804

8008201

A_23_P389897

GE57836

GO:0001540

GO:0001678

GO:0001942

GO:0004888

GO:0005035

GO:0005515

GO:0005516

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0005911

GO:0006351

GO:0006355

GO:0006886

GO:0006915

GO:0006919

GO:0007165

GO:0007266

GO:0007399

GO:0007411

GO:0007417

GO:0007623

GO:0008543

GO:0009986

GO:0010468

GO:0012501

GO:0014069

GO:0015026

GO:0016020

GO:0016048

GO:0021675

GO:0023052

GO:0030154

GO:0030336

GO:0030426

GO:0031069

GO:0031267

GO:0031410

GO:0031594

GO:0031625

GO:0032922

GO:0035907

GO:0038023

GO:0040037

GO:0042475

GO:0042488

GO:0042593

GO:0042995

GO:0043121

GO:0043197

GO:0043204

GO:0043226

GO:0043588

GO:0045202

GO:0048144

GO:0048146

GO:0048406

GO:0048511

GO:0048856

GO:0048870

GO:0051402

GO:0051799

GO:0060089

GO:0098793

GO:0099171

GO:1900182

GO:1902895

GO:1903588

GO:1904646

GO:2001235

HMNXSV003023040

ILMN_1752658

M14764_at

PH_hs_0025025

TC17000645.hg

g4505392_3p_at

Participates

as a component of

NF-kB:p75NTR ICD:TRAF6 [cytosol] (Homo sapiens)

as an input of

as an output of

gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)

Other forms of this molecule

NGFR [plasma membrane]

NGFR(29-250) [extracellular region]

NGFR(251-427) [plasma membrane]

NGFR(251-427) [endosome]

NGFR(251-272) [plasma membrane]

NGFR(273-427) [nucleoplasm]

Inferred To

NGFR [cytosol] (Bos taurus)

NGFR [cytosol] (Gallus gallus)

NGFR [cytosol] (Sus scrofa)

Ngfr [cytosol] (Mus musculus)

Ngfr [cytosol] (Rattus norvegicus)

NGFR(273-427) [cytosol] (Canis familiaris)

NGFR(273-427) [cytosol] (Danio rerio)

ngfr [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002498.1

Guide to Pharmacology - Targets

1888

OpenTargets

ENSG00000064300

ZINC - Substances

TNR16_HUMAN

ZINC target

P08138

PRO

P08138

PDB

3EWV, 2N97, 5ZGG, 2N80, 2N83, 7CSQ

GeneCards

P08138

HPA

ENSG00000064300-NGFR

Ensembl

ENSG00000064300, ENST00000172229, ENSP00000172229, ENST00000504201, ENSP00000421731

Pharos - Targets

P08138

ZINC - Predictions - Purchasable

TNR16_HUMAN

Orphanet

24760

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9CPR8	1	Nsmce3 [nucleoplasm] (R-MMU-2993761)	0.602	3
UniProt:P25233 NECD			0.602	3
UniProt:Q96FE5 LINGO1	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.589	2
UniProt:Q9Y467 SALL2			0.581	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.558	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.544	3
UniProt:O75509 TNFRSF21	1	TNFRSF21 [plasma membrane] (R-HSA-561169)	0.544	4
UniProt:P01138-PRO_0000019600 NGF			0.544	2
UniProt:P01138 NGF	7	NGF(19-241) [extracellular region] (R-HSA-187033) NGF [Golgi lumen] (R-HSA-166515) NGF [cytosol] (R-HSA-190059) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF [extracellular region] (R-HSA-167034)	0.544	2

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