Reactome | ARHGDIA [cytosol]

ARHGDIA [cytosol]

Stable Identifier

R-HSA-194478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RHO-GDIalpha, Rho GDP-dissociation inhibitor 1, GDIR_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P52565 ARHGDIA

Gene Names

ARHGDIA, GDIA1

Chain

initiator methionine:, chain:2-204

Reference Genes

BioGPS Gene:396 ARHGDIA

COSMIC (genes):ARHGDIA ARHGDIA

CTD Gene:396 ARHGDIA

dbSNP Gene:396 ARHGDIA

ENSEMBL:ENSG00000141522 ARHGDIA

ENSEMBL_homo_sapiens_GENE:ENSG00000141522.12 ARHGDIA

HGNC:678 ARHGDIA

KEGG Gene (Homo sapiens):396 ARHGDIA

Monarch:396 ARHGDIA

NCBI Gene:396 ARHGDIA

OMIM:601925 ARHGDIA

UCSC:P52565 ARHGDIA

Reference Transcript

Other Identifiers

11725049_s_at

11747409_s_at

11747512_s_at

11751074_x_at

16849970

201167_PM_x_at

201167_x_at

211716_PM_x_at

211716_x_at

213606_PM_s_at

213606_s_at

3774289

3774290

3774291

3774292

3774293

3774295

3774296

3774297

3774298

3774299

3774300

3774302

3774304

3774306

3774309

3774310

3774311

3774313

3774314

3774315

3774316

3774317

396

40164_at

4041385

4041386

4041387

4041388

4041389

4041390

4041391

4041392

4041394

4041396

4041399

4041400

4041402

4041403

4041404

4041405

4041406

8019263

8019765

A_23_P207766

A_24_P133933

A_24_P366994

GE59961

GO:0001772

GO:0005094

GO:0005096

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0007266

GO:0012501

GO:0016020

GO:0016192

GO:0023052

GO:0032880

GO:0035023

GO:0043066

GO:0043226

GO:0070062

GO:0071526

GO:0098685

GO:0098693

GO:0098772

Hs.159161.1.A1_3p_s_at

ILMN_1734742

PH_hs_0009664

TC17001961.hg

X69550_at

g13543380_3p_s_at

Participates

as a component of

as an input of

as a member of

Inferred To

Arhgdia [cytosol] (Mus musculus)

Arhgdia [cytosol] (Rattus norvegicus)

Homologues of ARHGDIA [cytosol] (Dictyostelium discoideum)

RDI1 [cytosol] (Saccharomyces cerevisiae)

ARHGDIA [cytosol] (Bos taurus)

ARHGDIA [cytosol] (Canis familiaris)

ARHGDIA [cytosol] (Gallus gallus)

ARHGDIA [cytosol] (Schizosaccharomyces pombe)

ARHGDIA [cytosol] (Sus scrofa)

arhgdia [cytosol] (Xenopus tropicalis)

rdiB [cytosol] (Dictyostelium discoideum)

rhi-1 [cytosol] (Caenorhabditis elegans)

zgc:77681 [cytosol] (Danio rerio)

RhoGDI [cytosol] (Drosophila melanogaster)

rdiA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001172006.1, NP_001288169.1, NP_001288171.1, NP_001172007.1, NP_004300.1, NP_001288172.1, NP_001288170.1

OpenTargets

ENSG00000141522

HPA

ENSG00000141522-ARHGDIA

GeneCards

P52565

Ensembl

ENSP00000269321, ENSP00000464205, ENST00000400721, ENSP00000441348, ENSP00000383556, ENST00000541078, ENSG00000141522, ENST00000269321, ENST00000580685

PRO

P52565

Pharos - Targets

P52565

Orphanet

22170

HMDB Protein

HMDBP01786

PDB

1QVY, 2JHV, 2JHZ, 2JHU, 2JI0, 1FT3, 2JHY, 2JHT, 2N80, 2BXW, 1CC0, 2JHS, 1KMT, 1FST, 1FSO, 2JHX, 1FT0, 1RHO, 1HH4, 2JHW

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.927	11
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.819	6
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.756	5
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.544	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:Q9NS68 TNR19			0.463	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.463	2