Reactome | ARHGDIA [cytosol]

ARHGDIA [cytosol]

Stable Identifier

R-HSA-194478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RHO-GDIalpha, Rho GDP-dissociation inhibitor 1, GDIR_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BSI4 TINF2

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External Reference Information

External Reference

UniProt:P52565 ARHGDIA

Gene Names

ARHGDIA, GDIA1

Chain

initiator methionine:, chain:2-204

Reference Genes

BioGPS Gene:396 ARHGDIA

COSMIC (genes):ARHGDIA ARHGDIA

CTD Gene:396 ARHGDIA

dbSNP Gene:396 ARHGDIA

ENSEMBL:ENSG00000141522 ARHGDIA

HGNC:678 ARHGDIA

KEGG:hsa:396 ARHGDIA

Monarch:396 ARHGDIA

NCBI Gene:396 ARHGDIA

OMIM:601925 ARHGDIA

UCSC:P52565 ARHGDIA

Reference Transcript

Other Identifiers

11725049_s_at

11747409_s_at

11747512_s_at

11751074_x_at

16849970

201167_PM_x_at

201167_x_at

211716_PM_x_at

211716_x_at

213606_PM_s_at

213606_s_at

3774289

3774290

3774291

3774292

3774293

3774295

3774296

3774297

3774298

3774299

3774300

3774301

3774302

3774303

3774304

3774305

3774306

3774307

3774308

3774309

3774310

3774311

3774312

3774313

3774314

3774315

3774316

3774317

396

40164_at

4041385

4041386

4041387

4041388

4041389

4041390

4041391

4041392

4041393

4041394

4041395

4041396

4041397

4041398

4041399

4041400

4041401

4041402

4041403

4041404

4041405

4041406

8019263

8019765

A_23_P207766

A_24_P133933

A_24_P366989

A_24_P366994

GE59961

GO:0001772

GO:0005094

GO:0005096

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0007266

GO:0016020

GO:0032880

GO:0035023

GO:0043066

GO:0043226

GO:0070062

GO:0071526

GO:0098685

GO:0098693

GO:0098772

Hs.159161.1.A1_3p_s_at

ILMN_1734742

PH_hs_0009664

TC17001961.hg

X69550_at

g13543380_3p_s_at

Participates

as a component of

as an input of

as a member of

Inferred To

Arhgdia [cytosol] (Mus musculus)

Arhgdia [cytosol] (Rattus norvegicus)

Homologues of ARHGDIA [cytosol] (Dictyostelium discoideum)

RDI1 [cytosol] (Saccharomyces cerevisiae)

ARHGDIA [cytosol] (Bos taurus)

ARHGDIA [cytosol] (Canis familiaris)

ARHGDIA [cytosol] (Gallus gallus)

ARHGDIA [cytosol] (Schizosaccharomyces pombe)

ARHGDIA [cytosol] (Sus scrofa)

arhgdia [cytosol] (Danio rerio)

arhgdia [cytosol] (Xenopus tropicalis)

rdiB [cytosol] (Dictyostelium discoideum)

rhi-1 [cytosol] (Caenorhabditis elegans)

RhoGDI [cytosol] (Drosophila melanogaster)

rdiA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001288172.1, NP_001288170.1, NP_001288171.1, NP_001172007.1, NP_001288169.1, NP_001172006.1, NP_004300.1

OpenTargets

ENSG00000141522

ENSEMBL

ENST00000400721, ENSP00000269321, ENSP00000441348, ENST00000541078, ENSP00000464205, ENSP00000383556, ENST00000580685, ENST00000269321

HPA

ENSG00000141522-ARHGDIA

PRO

P52565

Pharos - Targets

P52565

Orphanet

ARHGDIA

GlyGen

P52565

HMDB Protein

HMDBP01786

PDB

2BXW, 8X8T, 2JHZ, 2JHY, 1RHO, 2JHX, 1CC0, 2JI0, 2JHU, 2JHV, 2JHT, 2JHW, 1HH4, 1QVY, 1KMT, 2JHS, 1FSO, 1FT0, 1FT3, 1FST, 2N80

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.934	12
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.861	7
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.756	5
UniProt:P08134 RHOC	3	RHOC [plasma membrane] (R-HSA-194870) RHOC [cytosol] (R-HSA-194853) RHOC [endoplasmic reticulum membrane] (R-HSA-9714362)	0.564	2
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.547	2
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.544	2
UniProt:P84095 RHOG	4	RHOG [endoplasmic reticulum membrane] (R-HSA-5672084) RHOG [secretory granule membrane] (R-HSA-6804965) RHOG [cytosol] (R-HSA-194909) RHOG [plasma membrane] (R-HSA-194880)	0.527	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.463	2
UniProt:Q9NS68 TNR19			0.463	3

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